Neuroimaging and Molecular Markers in Alzheimer’s Disease: Data-Driven Meta-Analysis Research Background Alzheimer’s Disease (AD) is a chronic neurodegenerative disease characterized mainly by progressive memory loss and cognitive impairment, making it the most common type of dementia. Neuronal loss, one of the primary hallmarks of AD, is closely a...

Report on the Association Between Single Value Brain Activity Scores and the Progression of Alzheimer’s Disease Introduction Among the elderly population, cognitive decline and brain structural changes are widespread, even among healthy individuals1-3. Episodic memory, crucial for storing, maintaining, and retrieving single-event memories4, is espe...

In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...

This research explores the clinical value of plasma phosphorylated tau proteins (p-tau) 217 and 181 in assessing patients with mild cognitive impairment. Mild cognitive impairment may be a precursor stage of Alzheimer’s disease (AD), and early detection and monitoring of disease progression are crucial for disease management. Research Background: A...

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disorder, whose pathological mechanism involves multiple factors, including brain inflammation. Microglia, particularly those expressing the AD risk gene TREM2, are believed to play a crucial role in the development of AD, but their exact contribution has not been fully elucidated...