Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease

1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...

Activation of AMPK by GLP-1R Agonists Mitigates Alzheimer-Related Phenotypes in Transgenic Mice

I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...

Monocytes Can Efficiently Replace All Brain Macrophages and Fetal Liver Monocytes Can Generate Bona Fide Sall1+ Microglia

Academic Background The homeostasis of the central nervous system (CNS) relies on two key types of macrophages: microglia and border-associated macrophages (BAMs). Traditionally, microglia are believed to originate from the embryonic yolk sac and possess lifelong self-renewal capabilities, while bone marrow (BM)-derived monocytes in adults cannot r...

Deep Learning to Quantify the Pace of Brain Aging in Relation to Neurocognitive Changes

As the global aging problem intensifies, the incidence of neurodegenerative diseases (such as Alzheimer’s Disease, AD) is increasing year by year. Brain aging (Brain Aging, BA) is one of the significant risk factors for neurodegenerative diseases, but it does not completely align with chronological age (Chronological Age, CA). Traditional methods f...

Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...

Amyloid-Associated Hyperconnectivity Drives Tau Spread Across Connected Brain Regions in Alzheimer’s Disease

Amyloid-Associated Hyperconnectivity Drives Tau Spread in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and the abnormal aggregation and spread of tau protein in the brain. The traditional “amyloid cascade hypothesis” posits that...

Association of Objective Subtle Cognitive Difficulties with Amyloid-β and Tau Deposition in Alzheimer's Disease

Research Progress on Early Alzheimer’s Stages: Focusing on Differences Between Objective Subtle Cognitive Difficulties and Subjective Cognitive Decline Alzheimer’s disease (AD) is a critical topic in modern neuroscience and geriatric medicine research. Its pathological process begins years before the onset of clinical symptoms. Increasing evidence ...

The Influences of APOE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to MCRP

Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...

Plasma GFAP and p-tau-181 Association with Synaptic Density at 18F-SynVest-1 PET Imaging

Association of Plasma GFAP and p-tau-181 with Synaptic Density in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and tau protein aggregates in the brain. Recent research has shown that multiple factors are involved in the dev...

Gut-Induced Alpha-Synuclein and Tau Propagation Initiate Parkinson’s and Alzheimer’s Disease Co-Pathology and Behavior Impairments

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...