A Multicellular Mechanochemical Model to Investigate Tumor Microenvironment Remodeling and Pre-Metastatic Niche Formation

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering,
Tumor Microenvironment   Pre-Metastatic Niche   Computational Modeling   Epithelial-Mesenchymal Transition   Tumor Cells   Kupffer Cells   Stellate Cells  

Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths in the United States, with liver metastasis being a common occurrence. Before tumor metastasis, the formation of the Pre-Metastatic Niche (PMN) is a critical process. PMN involves the activation of key liver-resident cells, including fibroblast-like stellate cells and mac...

Retinal Pigment Epithelial Cells Reduce Vascular Leak and Proliferation in Retinal Neovessels

Medicine, Ophthalmology,
Epithelial-Mesenchymal Transition   Neovascularization   Macular Telangiectasia Type 2   Pigment Migration   Vascular Leakage   Retinal Imaging  

Retinal Pigment Epithelial Cells Reduce Vascular Leak and Proliferation in Retinal Neovessels Academic Background Retinal pigment epithelial cells (RPE cells) play a crucial role in various functions of the retina, including responding to stress and damage in the neuroretina. In many neurodegenerative diseases, such as age-related macular degenerat...

Epithelial−Mesenchymal Transition Induced by Tumor Cell-Intrinsic PD-L1 Signaling Predicts a Poor Response to Immune Checkpoint Inhibitors in PD-L1-High Lung Cancer

Medicine, Rheumatology and Immunology, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
PD-L1   Epithelial-Mesenchymal Transition   Non-Small-Cell Lung Cancer   Immune Checkpoint Inhibitors   Biomarkers   Tumor Progression  

Tumor Cell-Intrinsic PD-L1 Signaling Induces Epithelial-Mesenchymal Transition (EMT) Predicting Poor Response to Immune Checkpoint Inhibitors in PD-L1 High-Expressing Lung Cancer Research Background and Motivation In cancer immunotherapy, Programmed Death Ligand-1 (PD-L1) inhibits immune responses by binding to Programmed Death-1 (PD-1) receptors o...