A Multicellular Mechanochemical Model to Investigate Tumor Microenvironment Remodeling and Pre-Metastatic Niche Formation

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering,
Tumor Microenvironment   Pre-Metastatic Niche   Computational Modeling   Epithelial-Mesenchymal Transition   Tumor Cells   Kupffer Cells   Stellate Cells  

Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths in the United States, with liver metastasis being a common occurrence. Before tumor metastasis, the formation of the Pre-Metastatic Niche (PMN) is a critical process. PMN involves the activation of key liver-resident cells, including fibroblast-like stellate cells and mac...

Neutrophils Physically Interact with Tumor Cells to Form a Signaling Niche Promoting Breast Cancer Aggressiveness

Medicine, Oncology, Life Sciences,
Neutrophils   Breast Cancer   Signaling Niche   Tumor Microenvironment   Single-Cell RNA Sequencing  

Academic Background Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving interactions among multiple cell types and signaling pathways. In recent years, the role of the tumor microenvironment (TME) in cancer progression has gradually gained attention. Neutrophils, as an essential comp...

Local TSH/TSHR Signaling Promotes CD8+ T Cell Exhaustion and Immune Evasion in Colorectal Carcinoma

Medicine, Endocrinology, Gastroenterology, Oncology, Life Sciences, Immunology,
Thyroid Stimulating Hormone   Thyroid Stimulating Hormone Receptor   Colorectal Carcinoma   CD8+ T Cells   Immune Evasion   Tumor Microenvironment   Immune Checkpoint  

TSH/TSHR Signaling Promotes CD8+ T Cell Exhaustion and Immune Evasion in Colorectal Cancer Background Colorectal cancer (CRC) is one of the most common malignancies worldwide with high morbidity and mortality rates. Although immune checkpoint blockade (ICB) therapy has shown significant efficacy in some patients, the majority of CRC patients, parti...

Senescent Lung Fibroblasts in Idiopathic Pulmonary Fibrosis Facilitate Non-Small Cell Lung Cancer Progression by Secreting Exosomal MMP1

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Idiopathic Pulmonary Fibrosis   Non-Small Cell Lung Cancer   Exosomes   MMP1   PI3K-AKT-mTOR Pathway   Senescence-Associated Secretory Phenotype   Tumor Microenvironment  

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma

Medicine, Pharmacy, Oncology, Life Sciences, Immunology,
Pancreatic Ductal Adenocarcinoma   Tissue Factor   TREX1 Protein   cGAS-STING Pathway   Immune Evasion   Tumor Microenvironment   Targeted Therapy  

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma Academic Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies worldwide, with increasing incidence and mortality rates, particularly in advanced stages. Despite significant prog...