Prognostic Value of the CONUT Score in Immune Checkpoint Inhibitor Therapy for Metastatic Malignant Melanoma Academic Background The incidence of malignant melanoma (MM) is increasing annually, with approximately 20% of patients progressing to advanced or metastatic melanoma. Immune checkpoint inhibitors (ICIs) have significantly transformed the tr...

Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

The Role of Histone Demethylases in Autophagy and Inflammation Background Introduction Autophagy is an essential lysosomal degradation process in eukaryotic cells, playing a critical role in cellular component renewal and homeostasis maintenance. Dysregulation of autophagy is associated with various diseases, including cancer, inflammatory diseases...

Academic Background Duchenne Muscular Dystrophy (DMD) is a genetic muscular disorder and the most common type of muscular dystrophy in Japan. DMD is caused by a mutation in the dystrophin gene on the X chromosome, leading to the absence or defect of the dystrophin protein in muscle fibers. This results in a cascade of events, including increased mu...

Inflammation-Induced Epigenetic Imprinting and Intestinal Stem Cell Regulation In recent years, the scientific community has shown immense interest in the “memory” capabilities of non-immune cells, particularly the phenomenon where specific stem cells in adult tissues develop memory after undergoing inflammation, influencing their functionality. Ho...