Deep scSTAR: Leveraging Deep Learning for the Extraction and Enhancement of Phenotype-Associated Features from Single-Cell RNA Sequencing and Spatial Transcriptomics Data

In recent years, cutting-edge technologies such as single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have greatly advanced the development of life sciences and clinical medicine. These technologies have revealed cellular heterogeneity and brought novel insights into major fields such as disease, development, and immunity. Howe...

Flash Radiation Reprograms Lipid Metabolism and Macrophage Immunity and Sensitizes Medulloblastoma to CAR-T Cell Therapy

Background Brain tumors, particularly medulloblastoma (MB) in children, are one of the leading causes of cancer-related deaths in pediatric populations. Despite advancements in treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis for high-risk MB remains poor. In recent years, immunotherapy, especially CAR-T cell the...

CBL0137 and NKG2A Blockade: A Novel Immuno-Oncology Combination Therapy for MYC-Overexpressing Triple-Negative Breast Cancers

Academic Background and Problem Statement Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, accounting for 15-20% of all breast cancer cases. Due to the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), TNBC is insensitive to hormone the...

Generation of Allogeneic CAR-NKT Cells from Hematopoietic Stem and Progenitor Cells Using a Clinically Guided Culture Method

Generation of Clinically Applicable CAR-NKT Cells Research Background Chimeric Antigen Receptor (CAR) T cell therapy has been approved by the Food and Drug Administration (FDA) for the treatment of B-cell malignancies and multiple myeloma. However, the use of autologous CAR-T cell products presents challenges such as high costs, long manufacturing ...

The Role of SDCBP in Immunotherapy of Colorectal Cancer

Role of Syndecan Binding Protein (SDCBP) in Regulating Tumor Microenvironment, Tumor Progression, and Anti-PD1 Efficacy in Colorectal Cancer Background In recent years, immunotherapy has brought revolutionary advancements in cancer treatment. However, for colorectal cancer (CRC), anti-programmed cell death 1 (APD1) therapy shows relatively limited ...