Aging Promotes Reactivation of the Barr Body at Distal Chromosome Regions

Medicine, Rheumatology and Immunology, Obstetrics and Gynecology, Geriatrics, Neurology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
aging   Barr body   X chromosome inactivation   escape genes   chromatin accessibility   sex differences   epigenetics  

1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

A Single-Nuclei Paired Multiomic Analysis of the Human Midbrain Reveals Age- and Parkinson’s Disease–Associated Glial Changes

A Single-Nuclei Paired Multiomic Analysis of the Human Midbrain Reveals Age- and Parkinson’s Disease–Associated Glial Changes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Parkinson's disease   single-nuclei paired analysis   multiomic analysis   human midbrain   age-related changes   glial cells   chromatin accessibility  

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...