Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Modulation of Electrical Synapses and Excitability by Dopamine Receptors in the Thalamic Reticular Nucleus Academic Background The Thalamic Reticular Nucleus (TRN) is a thin shell of γ-aminobutyric acid (GABA)ergic inhibitory neurons in the thalamus. These neurons are coupled via gap junctions and regulate the transmission of sensory information fr...

Experience-Dependent Dopamine Modulation of Male Aggression

Experience-Dependent Dopamine Modulation of Male Aggression in Mice Academic Background Aggression is a common social behavior in the animal kingdom, crucial for territory defense, resource competition, and mate protection. Although the role of dopamine in regulating aggression has been extensively studied, its specific neural mechanisms remain unc...

Dopaminergic Psychostimulants Cause Arousal from Isoflurane-Induced Sedation Without Reversing Memory Impairment in Rats

Dopaminergic Psychostimulants Restore Arousal from Isoflurane-Induced Sedation Without Reversing Memory Impairment in Rats Academic Background The widespread use of anesthetic drugs in surgery allows patients to undergo treatment without pain. However, the impact of anesthetic drugs on memory has been a significant research topic in the field of an...

Intensity-Dependent Effects of TDCS on Motor Learning Are Related to Dopamine

The Intensity-Dependent Effects of Cortical Electrical Stimulation on Motor Learning and the Role of Dopamine Background Introduction Nowadays, non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) are widely used in neuroplasticity research to modulate cognition and behavior. However, optimizing stimulati...

YEATS2 Knockdown Impairs Dopaminergic Synaptic Integrity and Leads to Seizure-like Behaviors in Drosophila Melanogaster

A Study on the Effect of YEATS2 Gene Knockdown on Dopaminergic Synaptic Integrity and Epileptic-like Behavior in Drosophila Background Introduction Epilepsy is a common neurological disorder characterized by abnormal electrical activities in the brain. These abnormal activities can lead to seizures and other neurological symptoms. Familial adult my...