Resolving Native GABAA Receptor Structures from the Human Brain

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
GABAA receptor   structural analysis   epilepsy   cryo-electron microscopy   drug binding   neurotransmitter   human brain  

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

From Bedside to Bench: New Insights in Epilepsy-Associated Tumors Based on Recent Classification Updates and Animal Models on Brain Tumor Networks

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
low-grade neuroepithelial tumors   epilepsy   in utero electroporation   mouse model   neuronal activity   brain tumors   neuro-oncology  

Latest Research on Epilepsy-Associated Tumors: Classification and Animal Models Background Epilepsy is a common neurological disorder, and some patients are accompanied by brain tumors, particularly low-grade neuroepithelial tumors (LGNTs). These tumors typically grow slowly but are highly associated with drug-resistant epilepsy. Although research ...

GYS1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
GYS1   antisense oligonucleotide   epilepsy   Lafora disease   glycogen synthesis   neuroinflammation   neurodegeneration  

GYS1 Antisense Therapy Inhibits Pathogenic Aggregates and Epileptiform Discharges in a Mouse Model of Lafora Disease Background and Objectives Lafora disease (LD) is a devastating autosomal recessive genetic disorder characterized by epilepsy and rapidly progressive dementia in adolescence. The disease primarily involves mutations in the EPM2A or E...

Expanded Clinical Phenotype Spectrum Correlates with Variant Function in SCN2A-Related Disorders

Medicine, Basic Medical Sciences, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Genetics,
SCN2A   epilepsy   autism   developmental epileptic encephalopathy   ion channel   genetic variant  

Dysfunctional spectrum associated with clinical phenotype expansion in SCN2A-related disorders This paper was written by scholars including Anne T. Berg, Christopher H. Thompson, Leah Schust Myers, Erica Anderson, Lindsey Evans, Ariela J. E. Kaiser, Katherine Paltell, Amanda N. Nili, Jean-Marc L. Dekeyser, Tatiana V. Abramova, Gerry Nesbitt, Shawn ...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...