Neural Stem Cell-Derived Extracellular Vesicles Alleviate Inflammatory Responses in a Mouse Model of Atopic Dermatitis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
neural stem cells   extracellular vesicles   atopic dermatitis   inflammation   skin barrier   immune regulation   mouse model  

I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...

Modulation of Cardiac Automaticity by IKACH in the Sinoatrial Node During Pregnancy

Medicine, Obstetrics and Gynecology, Cardiovascular System,
pregnancy   sinoatrial node   acetylcholine-activated K+ current   heart rate   mouse model  

Academic Background Pregnant women undergo significant physiological changes in their cardiovascular system to meet the increased physiological demands during pregnancy. Among these changes, an increase in resting heart rate (HR) is common, typically rising by 10-20 beats per minute. However, this increase in HR can lead to the onset or exacerbatio...

Complete Inhibition of Liver Acetyl-CoA Carboxylase Activity Exacerbates Liver Tumorigenesis in Mice Treated with Diethylnitrosamine

Medicine, Hepatobiliary System, Oncology, Life Sciences, Biochemistry,
liver cancer   de novo lipogenesis   acetyl-CoA carboxylase   tumorigenesis   diethylnitrosamine   metabolic pathway   mouse model  

Inhibition of Liver Acetyl-CoA Carboxylase (ACC) Activity Exacerbates Liver Tumorigenesis in Mice Academic Background Liver cancer is the sixth most common cancer globally and the third leading cause of cancer-related mortality. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. In recent years, the burden of liver canc...

From Bedside to Bench: New Insights in Epilepsy-Associated Tumors Based on Recent Classification Updates and Animal Models on Brain Tumor Networks

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
low-grade neuroepithelial tumors   epilepsy   in utero electroporation   mouse model   neuronal activity   brain tumors   neuro-oncology  

Latest Research on Epilepsy-Associated Tumors: Classification and Animal Models Background Epilepsy is a common neurological disorder, and some patients are accompanied by brain tumors, particularly low-grade neuroepithelial tumors (LGNTs). These tumors typically grow slowly but are highly associated with drug-resistant epilepsy. Although research ...

Natural Killer Cells Promote Neutrophil Extracellular Traps and Restrain Macular Degeneration in Mice

Medicine, Basic Medical Sciences, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
natural killer cells   neutrophil extracellular traps   macular degeneration   mouse model   immune mechanisms  

Study on Macular Degeneration Reveals Inhibitory Effect of Natural Killer Cells on Disease Progression Background Age-related Macular Degeneration (AMD) is the leading cause of irreversible blindness among the elderly globally. With an aging population, the incidence of AMD is significantly increasing. Early features of AMD include the accumulation...

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice

Chemistry, Medicinal Chemistry, Medicine, Neurology, Pharmacy, Life Sciences, Biochemistry,
hearing loss   aminoglycosides   TRPV1   mouse model   protective mechanism  

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice Academic Background Hearing loss is a serious global health problem affecting over 400 million people worldwide, according to the World Health Organization. Aminoglycoside antibiotics, while widely used in medicine due to their broad-spectrum antibact...

Clonal Lineage Tracing with Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer

Medicine, Geriatrics, Urology, Oncology,
clonal lineage tracing   metastatic prostate cancer   barcodes   tumor evolution   mouse model   tumor heterogeneity  

title: “Utilizing Clonal Lineage Tracing with Recordable Barcodes Unveils the Migration History of Prostate Cancer Metastasis” author: Ryan N. Serio, Armin Scheben, *Billy Lu, *Domenic V. Gargiulo, Lucrezia Patruno, Caroline L. Buckholtz, Ryan J. Chaffee, Megan C. Jibilian, Steven G. Persaud, Stephen J. Staklinski, Rebecca Hassett, Lise M. Brault, ...