Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Medicine, Hepatobiliary System, Anesthesiology, Gastroenterology, Oncology,
pancreatic fistula   stereotactic radiotherapy   pancreatoduodenectomy   high-risk patients   fibrosis   safety   efficacy  

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...

Corticosteroids Combined with Low-Dose Methotrexate in the Treatment of Pemphigus Vulgaris: A Retrospective Cohort Study

Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
corticosteroids   methotrexate   pemphigus vulgaris   efficacy   safety  

Academic Background Pemphigus Vulgaris (PV) is a rare and severe autoimmune blistering disease characterized by a chronic course accompanied by multiple complications and side effects from medication. Currently, guidelines in many countries recognize systemic corticosteroids (CS) and rituximab (RTX) as first-line treatments for PV. However, due to ...

Revumenib for KMT2A-Rearranged Relapsed or Refractory Acute Leukemia: Efficacy and Safety

Medicine, Hematology, Oncology,
Revumenib   KMT2A-rearranged   acute leukemia   relapsed   refractory   safety   efficacy  

Academic Background Acute leukemia is a malignant hematologic disease caused by genetic mutations in hematopoietic cells, characterized by a block in differentiation during hematopoiesis and uncontrolled cellular proliferation. Among these, KMT2A gene rearrangements (KMT2A-rearranged, KMT2Ar) occur in up to 10% of acute leukemias in children and ad...

Phase Ib Trial of Neoadjuvant Oncolytic Virus OrienX010 and Toripalimab in Resectable Acral Melanoma

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Bioengineering, Immunology, Microbiology,
acral melanoma   neoadjuvant therapy   oncolytic virus   PD-1 inhibitors   tumor microenvironment   recurrence-free survival   safety  

Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...