Large-Scale Network Analysis of the Cerebrospinal Fluid Proteome Reveals Molecular Signatures of Frontotemporal Lobar Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
frontotemporal lobar degeneration   cerebrospinal fluid   proteomics   network analysis   genetic mutations   biomarkers  

Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...

Proteomic Analysis Reveals Distinct Cerebrospinal Fluid Signatures Across Genetic Frontotemporal Dementia Subtypes

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry, Genetics,
proteomics   frontotemporal dementia   cerebrospinal fluid   genetic mutations   neurodegenerative diseases  

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...

Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell analysis   neuroinflammation   cerebrospinal fluid   gene expression   immune cells   multiple sclerosis   lymphocyte clonal expansion  

Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...

Lumped Parameter Simulations of Cervical Lymphatic Vessels: Dynamics of Murine Cerebrospinal Fluid Efflux from the Skull

Physics, Fluid Physics, Engineering, Mechanical Engineering, Medicine, Neurology,
cervical lymphatic vessels   lymphatic system   cerebrospinal fluid   traumatic brain injury   numerical simulation   fluid dynamics   intracranial pressure  

Numerical Simulation Study of Cerebrospinal Fluid Drainage through Cervical Lymphatic Vessels Background Introduction Cerebrospinal fluid (CSF) is a clear fluid that circulates around the brain and spinal cord, providing physical protection, nutrient supply, and waste clearance for the central nervous system. In recent years, growing evidence sugge...

Numerical Study of the Effects of Minor Structures and Mean Velocity Fields in the Cerebrospinal Fluid Flow

Physics, Fluid Physics, Engineering, Mechanical Engineering, Medicine, Neurology, Life Sciences, Bioengineering,
cerebrospinal fluid   intrathecal injection   computational fluid dynamics   lagrangian velocity   spinal subarachnoid space   fluid transport   geometric variability  

Study on Cerebrospinal Fluid Flow Dynamics and Its Application in Drug Delivery Background Introduction Cerebrospinal fluid (CSF) plays a crucial role in the human spinal canal, responsible for transporting dissolved nutrients and waste products. Due to its pulsatile nature, CSF flow is influenced by cardiac and respiratory cycles. In recent years,...