Academic Background Macrophages in the central nervous system (CNS) include microglia and border-associated macrophages (BAMs). BAMs are distributed in the meninges, choroid plexus, and perivascular spaces, with perivascular macrophages (PVMs) being closely associated with cerebrovascular function. However, the mechanisms underlying BAM maintenance...

Academic Background Krabbe disease (also known as globoid cell leukodystrophy, GLD) is a fatal pediatric neurodegenerative disorder caused by mutations in the galactosylceramidase (GALC) gene. A hallmark pathological feature of this disease is the presence of lipid-laden globoid cells (GCs) in the central nervous system (CNS). Currently, hematopoie...

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent inflammation and ulceration of the colonic mucosa. Current treatments for UC primarily rely on immunosuppressive drugs, such as corticosteroids, immunomodulators, and biologics. However, the immunosuppressive properties of these drugs incr...

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

Academic Background Conjunctival Melanoma (COM) is a rare but potentially lethal ocular cancer, particularly when metastasis occurs, with limited treatment options. Although current treatments for primary conjunctival melanoma are relatively effective, once metastasis occurs, patient survival rates drop significantly, with most patients surviving l...