Alzheimer’s Disease and Age-Related Macular Degeneration: Shared and Distinct Immune Mechanisms

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
Alzheimer's Disease   Age-Related Macular Degeneration   Immune Mechanisms   Neuroinflammation   Therapeutic Strategies  

Academic Background Alzheimer’s disease (AD) and age-related macular degeneration (AMD) are the leading causes of cognitive impairment and vision loss in the elderly population worldwide. Although they affect different organs (the brain and the retina, respectively), recent studies have revealed shared pathological features, such as β-amyloid (Aβ) ...

Investigating Brain Lobe Biomarkers to Enhance Dementia Detection Using EEG Data

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging,
Electroencephalogram   Dementia   Alzheimer's Disease   Frontotemporal Dementia   Short-Time Fourier Transform   Convolutional Neural Networks  

Background Introduction Dementia is a global health issue that significantly impacts patients’ quality of life and places a substantial burden on healthcare systems. Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD) are two common types of dementia, and their overlapping symptoms make accurate diagnosis and targeted treatment development p...

Associations of Microbleeds and Their Topography with Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals with Down Syndrome

Medicine, Psychiatry, Geriatrics, Neurology, Medical Imaging,
Down Syndrome   Microbleeds   Alzheimer's Disease   Biomarkers   Imaging  

Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...

Epigallocatechin-3-Gallate Inhibits LPS/AβO-Induced Neuroinflammation in BV2 Cells Through Regulating the ROS/Txnip/NLRP3 Pathway

Medicine, Basic Medical Sciences, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's Disease   Amyloid β   Epigallocatechin-3-Gallate   NLRP3 Inflammasome   Txnip  

Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...

Herpes Simplex Virus 1 Accelerates the Progression of Alzheimer’s Disease by Modulating Microglial Phagocytosis and Activating NLRP3 Pathway

Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
Herpes Simplex Virus   Alzheimer's Disease   Microglia   NLRP3 Pathway   β-Amyloid   Neuroinflammation  

HSV-1 Infection Accelerates the Progression of Alzheimer’s Disease: Through the Regulation of Microglial Phagocytosis and Activation of the NLRP3 Pathway Research Background With the intensification of global aging, Alzheimer’s Disease (AD) has become a neurodegenerative disease affecting millions of people. In recent years, an increasing number of...