Microglial AKAP8L: A Key Mediator in Diabetes-Associated Cognitive Impairment via Autophagy Inhibition and Neuroinflammation Triggering

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
AKAP8L   mTOR   Diabetes-Associated Cognitive Impairment   Microglia   Autophagy   Neuroinflammation  

Key Mediator Akap8l in Microglia for Diabetes-Associated Cognitive Impairment: Functions via Autophagy Inhibition and Neuroinflammation Academic Background In recent years, diabetes-associated cognitive impairment (DACI) has received increasing attention. It not only poses a threat to the self-management capabilities of diabetic patients but also i...

Inflammatory Mechanisms in Traumatic Brain Injury and Post-Traumatic Epilepsy: A Study

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Traumatic Brain Injury   Post-Traumatic Epilepsy   Inflammasome Signaling   Microglia   NLRP3  

Neuroinflammation and Epilepsy: The Role of Inflammasomes in Traumatic Brain Injury Background and Purpose Traumatic Brain Injury (TBI) refers to changes in brain function and pathology resulting from physical trauma to the head or neck. Apart from common behavioral and psychological disorders, post-traumatic epilepsy (PTE) is one of the most sever...

Herpes Simplex Virus 1 Accelerates the Progression of Alzheimer’s Disease by Modulating Microglial Phagocytosis and Activating NLRP3 Pathway

Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
Herpes Simplex Virus   Alzheimer's Disease   Microglia   NLRP3 Pathway   β-Amyloid   Neuroinflammation  

HSV-1 Infection Accelerates the Progression of Alzheimer’s Disease: Through the Regulation of Microglial Phagocytosis and Activation of the NLRP3 Pathway Research Background With the intensification of global aging, Alzheimer’s Disease (AD) has become a neurodegenerative disease affecting millions of people. In recent years, an increasing number of...

Intermittent Hypoxia Exacerbates Anxiety in High-fat Diet-Induced Diabetic Mice by Inhibiting TREM2-Regulated IFNAR1 Signaling

Medicine, Respiratory System, Psychiatry, Endocrinology, Neurology,
Type 2 Diabetes Mellitus   Obstructive Sleep Apnea   Anxiety   Microglia   TREM2   IFNAR1   Cognition  

Over the past few decades, the incidence of type 2 diabetes mellitus (T2DM) has been on the rise, becoming a global public health issue. T2DM not only affects patients’ metabolic levels but also has profound impacts on cognitive function and mental health. Studies have shown that patients with T2DM exhibit brain structural abnormalities, a decline ...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Medicine, Infectious Diseases, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   PDCD4   Neuroinflammation   Depression   PPARγ   IL-10  

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...