A Conditional Protein Diffusion Model Generates Artificial Programmable Endonuclease Sequences with Enhanced Activity

A Conditional Protein Diffusion Model Generates Artificial Programmable Endonuclease Sequences with Enhanced Activity

Deep Learning-Driven Protein Design: Generating Functional Protein Sequences Using Conditional Diffusion Models Proteins are at the core of life sciences research and applications, offering countless possibilities due to their diversity and functional complexity. With advancements in deep learning technologies, protein design has reached a new pinn...

Auto-Segmentation of Neck Nodal Metastases Using Self-Distilled Masked Image Transformer on Longitudinal MR Images

Auto-Segmentation of Neck Nodal Metastases Using Self-Distilled Masked Image Transformer on Longitudinal MR Images

Potential of Self-Distilling Masked Image Transformer in Longitudinal MRI - Automatic Segmentation of Cervical Lymph Node Metastases Report Introduction In tumor radiotherapy, automatic segmentation technology promises to improve speed and reduce inter-reader variability caused by manual segmentation. In radiotherapy clinical practice, accurate and...

Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms

Protein Structure Prediction: Challenges, Progress, and Shifts in Research Paradigms Protein structure prediction is an important interdisciplinary research topic that has attracted researchers from various fields including biochemistry, medicine, physics, mathematics, and computer science. Researchers have adopted multiple research paradigms to so...

Enhancing Fall Risk Assessment: Instrumenting Vision with Deep Learning During Walks

Introduction Fall events are common across various clinical populations, with usual risk assessments including visual observation of individual gait. However, gait observation assessments are typically confined to laboratory settings, involving standardized walking protocol tests to identify potential defects that might increase fall risk. Subtle d...

Efficient Deep Learning-Based Automated Diagnosis from Echocardiography with Contrastive Self-Supervised Learning

Breakthrough in Automated Echocardiogram Diagnosis via Deep Learning: A Comparative Study of Self-Supervised Learning Methods Research Background With the rapid development of artificial intelligence and machine learning technologies, their role in medical imaging diagnosis is becoming increasingly significant. In particular, Self-Supervised Learni...