Monocytes Can Efficiently Replace All Brain Macrophages and Fetal Liver Monocytes Can Generate Bona Fide Sall1+ Microglia

Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
monocytes   brain macrophages   fetal liver monocytes   microglia   Alzheimer's disease   cell replacement therapy   epigenetics  

Academic Background The homeostasis of the central nervous system (CNS) relies on two key types of macrophages: microglia and border-associated macrophages (BAMs). Traditionally, microglia are believed to originate from the embryonic yolk sac and possess lifelong self-renewal capabilities, while bone marrow (BM)-derived monocytes in adults cannot r...

Role of Radiotherapy-Induced TREM1+ Mono-Macrophages in Rectal Cancer

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
radiotherapy   TREM1+   rectal cancer   monocytes   immunotherapy   antitumor immunity   biomarkers  

Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...

Functional and Epigenetic Changes in Monocytes from Adults Immunized with an AS01-Adjuvanted Vaccine

Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
vaccine   monocytes   AS01 adjuvant   epigenetics   immune response   activation  

Long-term Functional and Epigenetic Changes in Adult Monocytes Induced by AS01-adjuvanted Vaccine Background: Vaccine adjuvants are widely used to enhance the immune response of vaccines. In particular, the AS01 adjuvant, a key component in several approved vaccines, has demonstrated high immunogenicity and efficacy. AS01 exerts its adjuvant effect...