Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell analysis   neuroinflammation   cerebrospinal fluid   gene expression   immune cells   multiple sclerosis   lymphocyte clonal expansion  

Single-Cell Analysis Reveals Common Features of Neuroinflammation in Cerebrospinal Fluid Neuroinflammation is a core pathological feature of neurological diseases, involving complex interactions between the cerebrospinal fluid (CSF) and the peripheral immune system. Although previous studies have revealed the clonal expansion of lymphocytes in the ...

Reliability of Central Vein Sign Imaging with 3T FLAIR* in a Multicenter Study

Medicine, Neurology, Medical Imaging,
central vein sign   FLAIR*   multicenter study   multiple sclerosis   MRI   gadolinium contrast   diagnostic biomarker  

Reliability of Central Vein Sign Imaging with 3T FLAIR* in a Multicenter Study Academic Background Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by the formation of white matter lesions (WMLs). Magnetic Resonance Imaging (MRI) is a crucial tool for diagnosing and monitoring MS, particularly T2...

Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy

Medicine, Infectious Diseases, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
multiple sclerosis   anti-CD20   B-cell depletion   disease activity   long-term therapy   adverse events   immunotherapy  

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
cholesterol synthesis   multiple sclerosis   neurotoxicity   stem cells   inflammatory signaling   hypermetabolism   pharmacological treatment  

Lipid Metabolism Mechanisms in Neurodegenerative Diseases: A New Study on Multiple Sclerosis Multiple Sclerosis (MS) is a common inflammatory autoimmune demyelinating disease of the central nervous system (CNS). As the disease progresses, patients gradually experience neurological damage and disability. Although there have been advances in the trea...

Obesity Intensifies Sex-specific Interferon Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females

Obesity Intensifies Sex-specific Interferon Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Biochemistry, Immunology,
obesity   interferon signaling   sex differences   autoimmunity   central nervous system   multiple sclerosis  

Obesity Aggravates Female Central Nervous System Autoimmune Diseases Through Sex-Specific Interferon Signaling In recent years, the rising incidence of central nervous system (CNS) autoimmune diseases in females has garnered widespread attention. Obesity, as a potential environmental risk factor, has gradually become a research hotspot. The latest ...