Obesity-Associated Conditions Hinder Solute Drainage Function of Engineered Human Lymphatic Vessels

Obesity is a growing global health issue, closely linked to metabolic diseases such as cardiovascular diseases and diabetes, as well as lymphatic dysfunction. The lymphatic system plays a crucial role in maintaining fluid balance, immune responses, and fat metabolism. However, lymphatic function is often impaired in obese patients, leading to compl...

Raptin, a Sleep-Induced Hypothalamic Hormone, Suppresses Appetite and Obesity

In modern society, sleep deficiency has become one of the major causes of metabolic diseases. Studies have shown that insufficient sleep increases energy intake, but its effects on energy expenditure remain unclear. Although some clinical research indicates that sleep-deprived populations exhibit greater energy intake, energy expenditure does not c...

Amino Acid is a Major Carbon Source for Hepatic Lipogenesis

Research Report on the Relationship Between High Protein Diet and Liver Fat Synthesis Background and Significance Globally, the prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is gradually increasing, becoming a common issue among people with obesity and insulin resistance. The pathological development of this disease...

Obesity Intensifies Sex-specific Interferon Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females

Obesity Intensifies Sex-specific Interferon Signaling to Selectively Worsen Central Nervous System Autoimmunity in Females

Obesity Aggravates Female Central Nervous System Autoimmune Diseases Through Sex-Specific Interferon Signaling In recent years, the rising incidence of central nervous system (CNS) autoimmune diseases in females has garnered widespread attention. Obesity, as a potential environmental risk factor, has gradually become a research hotspot. The latest ...

A Multidimensional Analysis of the Impact of Obesity on Immune Checkpoint Inhibitor Therapy Efficacy

Background and Research Motivation Obesity has been identified as an important risk factor for various malignancies. It not only promotes the growth and spread of tumor cells but also leads to generally poorer prognosis in patients. However, recent research has found that obese patients receiving immune checkpoint inhibitors (ICI) therapy, especial...