Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Recovery from Spreading Depolarization is Slowed by Aging and Accelerated by Antioxidant Treatment in Locusts

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
spreading depolarization   aging   antioxidant   locusts   neural circuits   oxidative stress   Na+/K+-ATPase  

The Impact of Aging and Antioxidants on the Recovery from Spreading Depolarization in Locusts Academic Background Spreading Depolarization (SD) is a phenomenon that temporarily shuts down neural processing in both mammals and insects. In humans, SD is associated with various pathological states, such as migraine aura and neuronal death following tr...

Isorhamnetin Ameliorates Dopaminergic Neuronal Damage via Targeting FOSL1 to Activate AKT/mTOR in 6-OHDA-Induced SH-SY5Y Cells

Medicine, Neurology, Life Sciences,
Isorhamnetin   FOSL1   AKT/mTOR pathway   6-OHDA   Parkinson's disease   oxidative stress   apoptosis  

Isorhamnetin Ameliorates 6-OHDA-Induced SH-SY5Y Cell Damage by Targeting FosL1 to Activate the Akt/mTOR Pathway Academic Background Parkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra Pars Compacta (SNpc). This neuronal loss is closely associated with mitochondri...

Relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats

Medicine, Neurology, Neurosurgery,
oxidative stress   neuronal apoptosis   relaxin-2   ERK-nNOS-NO pathway   germinal matrix hemorrhage   rat model   neuroprotection  

rh-relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats Academic Background Germinal Matrix Hemorrhage (GMH) is one of the most common neurological disorders in newborns, particularly in preterm infants, and is a major cause of brain injury. GMH not only triggers acute inf...

Role of the Transcription Factor Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier

Medicine, Neurology, Life Sciences,
Nrf2   blood-brain barrier   inflammation   oxidative stress   neurological disorders   tight junction   phytochemicals  

The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...