Depletion of Squalene Epoxidase in Synergy with Glutathione Peroxidase 4 Inhibitor RSL3 Overcomes Oxidative Stress Resistance in Lung Squamous Cell Carcinoma

Medicine, Oncology,
lung squamous cell carcinoma   squalene epoxidase   terbinafine   reactive oxygen species   ferroptosis  

Lung cancer is one of the leading causes of death worldwide, with lung squamous cell carcinoma (LUSC) being a subtype of non-small cell lung cancer (NSCLC), accounting for 20%-30% of all NSCLC cases. Despite significant advancements in lung cancer treatment in recent years, LUSC still lacks effective targeted therapies, and patients have a poor pro...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Reduced Graphene Oxide-Mediated Electron–Hole Separation Using Titanium Dioxide Increases the Photocatalytic Antibacterial Activity of Bone Scaffolds

Materials Science, Medicine, Orthopedics, Life Sciences, Bioengineering,
reduced graphene oxide   photocatalysis   reactive oxygen species   antibacterial properties   bone scaffold   titanium dioxide   electron-hole separation  

Study on Reduced Graphene Oxide-Mediated Titanium Dioxide Photocatalytic Antibacterial Bone Scaffolds Academic Background Bacterial infection is one of the most common complications following the implantation of artificial bone scaffolds during bone defect repair. Bacteria form biofilms on the scaffold surface, releasing acids and enzymes that inte...

Electrospun Polyvinyl Alcohol Fibres Incorporating an Antimicrobial Gel for Enzymatically Controlled Reactive Oxygen Species Release

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Life Sciences, Biochemistry, Bioengineering, Microbiology,
antimicrobial   electrospinning   hydrogen peroxide   polyvinyl alcohol   reactive oxygen species   tissue engineering   wound dressing  

Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...

Oxyglutamate Carrier Alleviates Cerebral Ischaemia–Reperfusion Injury by Regulating Mitochondrial Function

Medicine, Neurology, Life Sciences,
cerebral ischaemia–reperfusion injury   mitochondrial function   neuron   oxyglutamate carrier   reactive oxygen species  

The Role of Oxyglutamate Carrier in Cerebral Ischemia-Reperfusion Injury Academic Background Cerebral ischemia-reperfusion injury (I/R) is a significant issue in the treatment of ischemic stroke. Although rapid blood flow restoration through thrombectomy and intravenous rt-PA (recombinant tissue plasminogen activator) administration can effectively...