Gene-Level Alignment of Single-Cell Trajectories

Medicine, Life Sciences, Cell Biology, Immunology, Genetics,
single-cell RNA sequencing   pseudotime trajectory inference   dynamic time warping   gene expression   cell state  

Gene-level Single-cell Trajectory Alignment: A New Method Based on Dynamic Programming The advent of single-cell RNA sequencing (scRNA-seq) technology has dramatically advanced biological research, enabling scientists to observe dynamic changes at the single-cell level over time and space. However, comparing such dynamics across samples or conditio...

Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis

Medicine, Oral Sciences, Life Sciences, Immunology,
periodontitis   single-cell RNA sequencing   keratinocytes   immune interactions   bacterial infection   spatial phenotyping   chronic inflammation  

Single-Cell and Spatially Resolved Interactomics of Tooth-Associated Keratinocytes: Exploring the Role of Structural Immunity in Periodontitis Background Periodontitis is a chronic inflammatory disease that affects the periodontal tissues and impacts billions of people globally, potentially resulting in tooth loss. It is primarily caused by polybac...

Exploring Cervical Adenocarcinoma: Epidemiological Insights, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms

Medicine, Obstetrics and Gynecology, Oncology,
cervical adenocarcinoma   cervical cancer   gynecological oncology   organoid   single-cell RNA sequencing   tumor microenvironment  

Exploring Cervical Adenocarcinoma: Epidemiology, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms Academic Background Cervical cancer poses a significant threat to women’s health globally, particularly in developing countries. The main histological types of cervical cancer include squamous cell carcinoma (SCC) and cervical adenoca...

Integrative Analysis of Ewing’s Sarcoma Reveals the MIF-CD74 Axis as a Target for Immunotherapy

Medicine, Oncology, Life Sciences, Immunology,
Ewing’s sarcoma   immunotherapy   MIF-CD74 axis   tumor microenvironment   single-cell RNA sequencing  

Discovery of a New Immunotherapy Target for Ewing Sarcoma Background Introduction Ewing sarcoma (Ewing’s sarcoma, EWS) is a common pediatric bone cancer, accounting for approximately 2% of childhood cancers. Despite significant advances in immune checkpoint inhibitors (ICIs) and CAR-T cell therapy in various cancers, their efficacy in Ewing sarcoma...

Meningeal Solitary Fibrous Tumor Cell States Phenocopy Cerebral Vascular Development and Homeostasis

Medicine, Neurology, Neurosurgery, Oncology,
meningeal solitary fibrous tumor   single-cell RNA sequencing   spatial transcriptomics   cell-cell interactions   cerebral vascular development   tumor microenvironment   WHO histological grading  

Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...

BRD4 Inhibitor Reduces Exhaustion and Blocks Terminal Differentiation in CAR-T Cells by Modulating BATF and EGR1

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CAR-T cell exhaustion   BRD4 inhibitor   single-cell RNA sequencing   transcriptional factors   acute myeloid leukemia  

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...