Exosomes Derived from Exercise-Trained Mice Bone Marrow Mesenchymal Stem Cells Improve Wound Healing by Inhibiting Macrophage M1 Polarization

Medicine, Rheumatology and Immunology, Oral Sciences, Sports Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
bone marrow mesenchymal stem cells   exosome   treadmill exercise   macrophage polarization   M1   wound healing   inflammation  

I. Academic Background and Research Significance Wound healing is a highly complex physiological process that plays a crucial role in tissue regeneration, repair, and immune regulation. However, poor healing of chronic wounds is clinically widespread, severely impacting patients’ quality of life and increasing medical and socioeconomic burdens. The...

METTL3 Promotes Osteogenesis by Regulating N6-Methyladenosine-Dependent Primary Processing of hsa-mir-4526

Medicine, Orthopedics, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
METTL3   osteogenesis   N6-methyladenosine   miRNA processing   hsa-mir-4526   adipose stem cells   bone repair  

New Mechanism of m6A Methylation Promoting Osteogenic Differentiation of Adipose-Derived Stem Cells Revealed — Study Based on METTL3-Mediated Primary microRNA Splicing Regulation of hsa-mir-4526 1. Academic Background and Research Motivation Bone tissue engineering has emerged as a cutting-edge interdisciplinary research field due to rapid advances...

Oral-Anatomical Knowledge-Informed Semi-Supervised Learning for 3D Dental CBCT Segmentation and Lesion Detection

Information Science, Computer Science, Automation, Medicine, Oral Sciences, Medical Imaging,
dental CBCT   semi-supervised learning   lesion detection   oral-anatomical knowledge   3D image segmentation  

Academic Background and Research Motivation In the field of dental healthcare, Cone Beam Computed Tomography (CBCT) is a widely used three-dimensional imaging technique. CBCT provides three-dimensional images of the oral cavity and is particularly effective in diagnosing odontogenic lesions. However, the segmentation of CBCT images—labeling each vo...

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Immunology,
Cold Atmospheric Plasma   Oral Ulcers   Nanogel   Inflammation Regulation   Epidermal Growth Factor Receptor   Biocompatibility   Therapeutic Enhancement  

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

New Advances in Periodontal Functional Materials Based on Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies

Chemistry, Nanoscience, Polymer Chemistry, Medicinal Chemistry, Medicine, Oral Sciences, Life Sciences, Biochemistry, Bioengineering, Immunology, Microbiology,
periodontitis   antibacterial materials   anti-inflammatory therapy   tissue regeneration   multifunctional materials   biomaterials   innovative treatment  

A Review on Novel Periodontal Functional Materials: Comprehensive Exploration of Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies Academic Background and Research Significance With the accelerating trend of global population aging, the concern for oral health issues is increasing. Periodontitis, as a common bacterial infectious ...