Determining Risk Features for Medulloblastoma in the Molecular Era

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   molecular classification   risk stratification   radiation therapy   methylation profiling   chemotherapy   survival rate  

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases: A Report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group

Medicine, Pediatrics, Oncology,
rhabdomyosarcoma   lung metastases   whole lung irradiation   Children’s Oncology Group   survival rate  

Efficacy of Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases Academic Background Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children. Despite advancements in treatment, the prognosis for patients with metastatic RMS remains poor, especially for those with lung metastases, whose survival rates are significantly lower th...

A Multidimensional Analysis of the Impact of Obesity on Immune Checkpoint Inhibitor Therapy Efficacy

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
obesity   immune checkpoint inhibitors   inflammation   survival rate   cancer  

Background and Research Motivation Obesity has been identified as an important risk factor for various malignancies. It not only promotes the growth and spread of tumor cells but also leads to generally poorer prognosis in patients. However, recent research has found that obese patients receiving immune checkpoint inhibitors (ICI) therapy, especial...

Association of Timely Comprehensive Genomic Profiling with Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer

Association of Timely Comprehensive Genomic Profiling with Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer

Medicine, Respiratory System, Oncology,
non-small-cell lung cancer   genomic profiling   precision oncology   immune checkpoint inhibitors   survival rate   treatment selection  

Study on the Association Between the Timeliness of Comprehensive Genomic Profiling in Precision Oncology and Treatment Choices and Outcomes for Patients with Advanced Non-Small Cell Lung Cancer Introduction Advanced non-small-cell lung cancer (ANSCLC) is a highly lethal malignancy, and treatment choices directly affect the overall survival rate of ...

Efficacy-Effectiveness Analysis on Survival in a Population-Based Real-World Study of BRAF-Mutated Metastatic Colorectal Cancer Patients Treated with Encorafenib-Cetuximab

Medicine, Basic Medical Sciences, Gastroenterology, Oncology, Life Sciences, Genetics,
BRAF mutation   metastatic colorectal cancer   Encorafenib   Cetuximab   real-world study   survival rate   efficacy  

Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...