Light/pH Dual Controlled Drug Release 'Nanocontainer' Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
nanocontainer   tumor hypoxia   photodynamic therapy   chemodynamic therapy   Fenton effect   multimodal therapy   targeted therapy  

Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...

Cryptoic Acids A and B, Benzene-Containing Polyketides, and Cyclocryptamide, a Modified Diketopiperazine, from an Actinomycete of the Genus Cryptosporangium

Chemistry, Organic Chemistry, Medicinal Chemistry, Life Sciences, Biochemistry, Microbiology,
Cryptosporangium   polyketides   diketopiperazine   biological activity   actinomycetes   natural products   drug discovery  

Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...

Therapeutic Potential of Isoallolithocholic Acid in Methicillin-Resistant Staphylococcus aureus Peritoneal Infection

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Methicillin-Resistant Staphylococcus aureus   Isoallolithocholic Acid   Peritoneal Infection   Antibacterial Activity   Biofilm Formation   Bacterial Membrane Permeability   Macrophage Phagocytosis  

Therapeutic Potential of Isoallolithocholic Acid in Methicillin-Resistant Staphylococcus aureus Peritoneal Infection Background Methicillin-resistant Staphylococcus aureus (MRSA), discovered in 1961, has become one of the most common antibiotic-resistant bacteria worldwide. MRSA infections can lead to fatal sepsis, pneumonia, and high rates of skin...

Inhibitors of Acetohydroxyacid Synthase as Promising Agents Against Non-Tuberculous Mycobacterial Diseases

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Microbiology,
Acetohydroxyacid Synthase   Non-Tuberculous Mycobacteria   Drug Development   Antimicrobial Activity   Structural Modification   Synergistic Effect   Drug Resistance  

New Hope for the Treatment of Non-Tuberculous Mycobacterial Diseases—Research on Acetohydroxyacid Synthase Inhibitors Academic Background Non-tuberculous mycobacteria (NTM) infections have become an important cause of pulmonary diseases worldwide in recent years, especially among immunocompromised populations. The treatment of NTM infections faces ...

Novobiocin primarily targets ParE in Neisseria gonorrhoeae

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Microbiology,
novobiocin   Neisseria gonorrhoeae   drug resistance   DNA topoisomerase   antibacterial agents  

Novobiocin Primarily Targets ParE in Neisseria gonorrhoeae Background Neisseria gonorrhoeae is a Gram-negative bacterium that causes gonorrhea, one of the most common sexually transmitted infections worldwide. According to the World Health Organization (WHO), there were 82.3 million new cases of gonorrhea among people aged 15–49 in 2020. However, t...