Direct Observation of Small Molecule Activator Binding to Single PR65 Protein

Chemistry, Medicinal Chemistry, Medicine, Life Sciences, Biochemistry, Biophysics,
Protein Phosphatase 2A   Small Molecule Activator   Nanoaperture Optical Tweezers   Binding Kinetics   Molecular Dynamics Simulation  

Single-Molecule Optical Tweezer Technique Reveals the Binding Mechanism of a Small Molecule Activator and PR65 Protein Academic Background Protein phosphatase 2A (PP2A) is a crucial enzyme in regulating cellular signaling. Its dysfunction is closely associated with various cancers and chronic diseases, such as Alzheimer’s disease and chronic obstru...

The Development and Application of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Biochemistry, Bioengineering,
levodopa   Parkinson's disease   direct electron transfer enzyme   biosensor   continuous monitoring  

Development of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring Background Parkinson’s Disease (PD) is a chronic neurodegenerative disease that affects millions of people worldwide. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein aggregations forming Lew...

Advancements of Paper-Based Sensors for Antibiotic-Resistant Bacterial Species Identification

Chemistry, Nanoscience, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
paper-based sensors   antibiotic resistance   bacterial infections   nanoparticles   detection techniques  

Advances in Paper-Based Sensors for the Detection of Antibiotic-Resistant Bacteria Background Antimicrobial resistance (AMR) is one of the most significant global public health challenges today. With the extensive use and misuse of antibiotics, more and more bacteria have developed resistance, rendering traditional treatments ineffective. According...

Photothermal MXene-Embedded Tannin–Eu3+ Particles as In Situ Bacterial Vaccines for Accelerating Healing of Wounds Infected by Seawater Immersion and Providing Persistent Anti-Infection Effects

Chemistry, Nanoscience, Materials Science, Medicine, Infectious Diseases, Life Sciences, Biochemistry, Bioengineering, Immunology,
MXene   Tannin   Wound Healing   Anti-infection   In Situ Vaccine  

Photothermal MXene-Embedded Tannin-Eu³⁺ Particles as In Situ Bacterial Vaccines for Seawater-Immersed Infected Wounds Academic Background Seawater-immersed wounds are prone to severe infections due to the low temperature, high salinity, and bacteria-rich environment, which hinder wound healing. Traditional antibacterial strategies often fail to pro...

Electrospun Polyvinyl Alcohol Fibres Incorporating an Antimicrobial Gel for Enzymatically Controlled Reactive Oxygen Species Release

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Life Sciences, Biochemistry, Bioengineering, Microbiology,
antimicrobial   electrospinning   hydrogen peroxide   polyvinyl alcohol   reactive oxygen species   tissue engineering   wound dressing  

Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...