Surface Structural Changes in Silicone Rubber Due to Electrical Tracking

Chemistry, Polymer Chemistry, Materials Chemistry, Engineering, Electrical Engineering, Materials Science, Organic Polymeric Materials, Information Science, Computer Science,
silicone rubber   electrical insulators   tracking   ATR-FTIR spectroscopy   two-dimensional correlation spectroscopy   aging   surface roughness  

Cutting-Edge Scientific News: Research Reveals Degradation Mechanisms of Silicone Rubber under Electrical Tracking Background: Motivation and Challenges With the rapid development of power transmission and distribution systems, polymer composite insulators have gradually replaced traditional glass and ceramic insulators as the preferred materials f...

A Foundation Model for Joint Segmentation, Detection and Recognition of Biomedical Objects Across Nine Modalities

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Imaging,
biomedical image analysis   joint learning   segmentation   detection   recognition   multimodal   foundation model  

Decoding the Future of Biomedical Image Analysis: A Foundational Model for Multi-Modal Joint Segmentation, Detection, and Recognition Background In biomedical research, image analysis has become a crucial tool for advancing discoveries, enabling multi-scale studies ranging from organelles to organs. However, traditional biomedical image analysis of...

EvoAI Enables Extreme Compression and Reconstruction of the Protein Sequence Space

Information Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Genetics,
protein engineering   deep learning   sequence space compression   high-dimensional space   biomolecular design  

Extreme Compression and Reconstruction of Protein Sequence Space: A Breakthrough Study on EvoAI Background Protein design and optimization have become central challenges in fields like biotechnology, medicine, and synthetic biology. The functions of proteins are determined by their sequences and structures, but this functional sequence space is hig...

Evaluation of Large Language Models for Discovery of Gene Set Function

Information Science, Artificial Intelligence, Medicine, Life Sciences, Biochemistry, Genetics,
Large Language Models   Gene Set Function   Functional Genomics   Gene Ontology   Bioinformatics   Artificial Intelligence   Gene Expression  

Exploration of Gene Set Function Discovery Using Large Language Models: GPT-4 Excels Academic Background In functional genomics, gene set enrichment analysis is a critical methodology for understanding gene functions and their associated biological processes. However, existing enrichment analyses rely heavily on curated gene function databases, suc...

Overcoming the Preferred-Orientation Problem in Cryo-EM with Self-Supervised Deep Learning

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Biophysics,
cryo-EM   preferred-orientation problem   self-supervised learning   deep learning   3D reconstruction   molecular structure   biological macromolecules  

Overcoming the Preferred-Orientation Problem in Single-Particle Cryo-EM: An Innovative Solution through Deep Learning Background Introduction In recent years, single-particle cryogenic electron microscopy (Single-Particle Cryo-EM) has become a core technique in structural biology due to its ability to resolve the atomic-resolution structures of bio...

Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...