The Mevalonate Pathway Contributes to Breast Primary Tumorigenesis and Lung Metastasis

Medicine, Oncology,
mevalonate pathway   breast cancer   lung metastasis   Rho GTPases   cholesterol   gene expression   tumor recurrence  

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

Epigenome-Wide Association Studies Identify Novel DNA Methylation Sites Associated with PTSD: A Meta-Analysis of 23 Military and Civilian Cohorts

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
PTSD   DNA methylation   post-traumatic stress disorder   epigenetics   gene expression   meta-analysis   genome-wide association studies  

Epigenome-wide DNA Methylation Study Highlights PTSD-Associated Sites: A Meta-Analysis Across 23 Military and Civilian Cohorts Background and Research Objectives Post-Traumatic Stress Disorder (PTSD) is a serious psychiatric condition triggered by exposure to traumatic events. It is characterized by intrusive memories, avoidance or emotional numbne...

PITX2 Expression and Neanderthal Introgression in HS3ST3A1 Contribute to Variation in Tooth Dimensions in Modern Humans

Medicine, Oral Sciences, Life Sciences, Genetics,
tooth morphology   gene expression   Neanderthal   tooth development   genome-wide association analysis  

“PITX2 Expression and Neanderthal Introgression in HS3ST3A1 Contribute to Variation in Tooth Dimensions in Modern Humans” Source of the Research This paper was authored by Qing Li, Pierre Faux, Emma Wentworth Winchester, and others, and published on January 6, 2025, in the journal Current Biology. The authors come from various research institutions...

Follicular Lymphoma Comprises Germinal Center–Like and Memory-Like Molecular Subtypes with Prognostic Significance

Medicine, Hematology, Oncology, Life Sciences, Immunology,
follicular lymphoma   molecular subtypes   prognosis   immunohistochemistry   gene expression   treatment response   precision medicine  

Progress in Molecular Classification of Follicular Lymphoma: A Dual Typing Predictive Model Based on RNA Sequencing and Immunohistochemistry Follicular Lymphoma (FL) is a B-cell malignancy characterized by a slow clinical progression, with a median overall survival extending up to 20 years. However, the heterogeneous nature of FL leads to significa...

Revumenib Revises the Treatment Landscape for KMT2A-R Leukemia

Medicine, Hematology, Oncology,
Revumenib   KMT2A-R leukemia   menin inhibitors   gene expression   clinical trial   leukemia cell differentiation   drug resistance  

Revumenib Alters the Treatment Landscape for KMT2A-Rearranged Leukemia Academic Background Leukemia is a malignant disease caused by abnormalities in the hematopoietic system, with KMT2A-rearranged (KMT2A-r) leukemia being a common subtype, particularly in pediatric and adult acute myeloid leukemia (AML). Rearrangements of the KMT2A gene (lysine me...

Population-wide DNA Methylation Polymorphisms at Single-Nucleotide Resolution in 207 Cotton Accessions Reveal Epigenomic Contributions to Complex Traits

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Botany,
cotton   DNA methylation   gene expression   epigenetics   fiber quality  

Cotton Population-Level DNA Methylation Polymorphism Study Reveals Epigenomic Contributions to Complex Traits Background and Research Motivation In recent decades, genome and genetic diversity have been extensively studied through genome-wide association studies (GWAS), providing a theoretical foundation for understanding crop trait variations. How...