The Oxygen Isotope Identity of the Earth and Moon with Implications for the Formation of the Moon and Source of Volatiles Academic Background The isotopic similarity between Earth and Moon rocks has long been a significant puzzle in geochemistry and cosmochemistry, contradicting prevailing models of Moon formation, particularly the “Giant Impact Th...

Exploring, Sampling, and Interpreting Lunar Volatiles in Polar Cold Traps Academic Background The permanently shadowed regions (PSRs) at the lunar poles, along with other surface volatile deposits, are critical sampling targets for future human missions to the Moon. These volatiles hold significant scientific value and could potentially shift strat...

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Deciphering Antagonist Selectivity of Endothelin Receptors: Insights from Cryo-EM-Based Structural Studies Academic Background Endothelin (ET) is a potent vasoconstrictor peptide that plays a significant role in regulating cardiovascular functions. The endothelin family includes ET-1, ET-2, and ET-3, which regulate vascular tone and cardiovascular ...

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...