High-yield Porphyrin Production Through Metabolic Engineering and Biocatalysis

High-yield Porphyrin Production Through Metabolic Engineering and Biocatalysis

Chemistry, Organic Chemistry, Catalysis, Chemical Engineering, Life Sciences, Biochemistry, Bioengineering,
metabolic engineering   biocatalysis   porphyrin   heme   zincphyrin   bacteria   fermentation  

This study was published in the journal Nature Biotechnology, with the doi 10.1038/s41587-024-02267-3. The corresponding authors are Haihong Chen and Yaohong Wang from East China University of Science and Technology, and the publication date is April 26, 2024. The article investigates the high-yield production of chlorophyll through metabolic engin...

Development of Complemented Comprehensive Networks for Rapid Screening of Repurposable Drugs Applicable to New Emerging Disease Outbreaks

Chemistry, Medicinal Chemistry, Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Pharmacy, Life Sciences, Immunology, Microbiology,
drug repurposing   network medicine   graph-based semi-supervised learning   COVID-19  

Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...

An Explicit Estimated Baseline Model for Robust Estimation of Fluorophores Using Multiple-Wavelength Excitation Fluorescence Spectroscopy

Physics, Optics, Chemistry, Analytical Chemistry, Medicine, Medical Laboratory Science, Neurology, Neurosurgery, Medical Imaging, Oncology, Life Sciences, Bioengineering,
fluorescence spectroscopy   multiple-wavelength excitation   fluorophores   baseline model   non-linear optics   neuro-oncology   glioma  

Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...

Evidence for Electron–Hole Crystals in a Mott Insulator

Physics, Quantum Physics, Condensed Matter Physics, Chemistry, Physical Chemistry, Materials Science,
electron-hole crystals   Mott insulator   graphene   scanning tunneling microscopy   long-range quantum entanglement  

Background In recent years, researchers have shown significant interest in electron-hole crystals within Mott insulators. These types of crystals can achieve quantum excited states, have the potential to support counterflow superfluidity and topological order, and possess long-range quantum entanglement characteristics. However, experimental eviden...

Supramolecular Assembly Activated Single-Molecule Phosphorescence Resonance Energy Transfer for Near-Infrared Targeted Cell Imaging

Chemistry, Organic Chemistry, Nanoscience, Medicinal Chemistry, Life Sciences, Biochemistry, Biophysics,
supramolecular assembly   single-molecule phosphorescence   resonance energy transfer   near-infrared imaging   cancer targeting  

Supramolecular Assembly-Activated Single-Molecule Phosphorescence Resonance Energy Transfer for Near-Infrared Targeted Cell Imaging In recent years, pure organic phosphorescence resonance energy transfer (PRET) research has become a hot topic. In this paper, the authors constructed a single-molecule PRET system with a large Stokes shift (367 nm) an...