Hierarchical Design of Pseudosymmetric Protein Nanocages

Chemistry, Nanoscience, Life Sciences, Biochemistry, Bioengineering,
protein design   nanomaterials   self-assembly   pseudosymmetry   computational biology  

Academic Background Protein self-assembly is a ubiquitous phenomenon in biological systems, performing a wide range of functions from structural support to biochemical regulation. Despite significant progress in protein design in recent years, existing self-assembling protein structures typically rely on strict symmetry, which limits their size and...

Four-Component Protein Nanocages Designed by Programmed Symmetry Breaking

Chemistry, Nanoscience, Life Sciences, Biochemistry, Bioengineering,
protein nanocages   symmetry breaking   virus structure   vaccine design   targeted delivery  

Design of Four-Component Protein Nanocages through Programmed Symmetry Breaking Academic Background Protein nanocages are highly symmetric protein assemblies widely used in vaccine development, drug delivery, and nanomaterial design. In nature, viruses often construct complex structures through symmetry breaking, particularly in high triangulation ...

Growth-Based Monolithic 3D Integration of Single-Crystal 2D Semiconductors

Chemistry, Nanoscience, Engineering, Electrical Engineering, Materials Science, Information Science, Semiconductors and Information Devices,
3D integration   single-crystal growth   2D semiconductors   transition metal dichalcogenides   low-temperature processing  

Research on Growth-Based Monolithic 3D Integration of Single-Crystal 2D Semiconductors Academic Background With the rapid development of the modern electronics industry, three-dimensional (3D) integration technology has gradually become an important means to enhance the performance of electronic devices. Traditional two-dimensional (2D) integrated ...

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Pharmacy, Life Sciences, Biochemistry, Microbiology,
Caseinolytic Protease P   Antistaphylococcal Agents   ZG297   MRSA   Structure-Guided Design   Selective Agonists   Antibiotics  

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

Inferring Phase Transitions and Critical Exponents from Limited Observations with Thermodynamic Maps

Physics, Thermodynamics, Chemistry, Physical Chemistry, Life Sciences, Biophysics,
phase transitions   thermodynamic maps   critical exponents   statistical mechanics   RNA systems  

Inferring Phase Transitions and Critical Exponents from Limited Observations with Thermodynamic Maps Academic Background Phase transitions are ubiquitous phenomena in nature, ranging from the boiling of water to the ferromagnetic-paramagnetic transition in magnetic materials, and even to conformational changes in biomolecules such as proteins and n...