Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice

Chemistry, Medicinal Chemistry, Medicine, Neurology, Pharmacy, Life Sciences, Biochemistry,
hearing loss   aminoglycosides   TRPV1   mouse model   protective mechanism  

Piplartine Attenuates Aminoglycoside-Induced TRPV1 Activity and Protects from Hearing Loss in Mice Academic Background Hearing loss is a serious global health problem affecting over 400 million people worldwide, according to the World Health Organization. Aminoglycoside antibiotics, while widely used in medicine due to their broad-spectrum antibact...

Sequence-Based Functional Metagenomics Reveals Novel Natural Diversity of Cu Resistance Gene copa in Environmental Microbiomes

Chemistry, Environmental Chemistry, Life Sciences, Biochemistry, Bioengineering, Microbiology,
Functional Metagenomics   Natural Diversity   Cu Resistance   Evolutionary Trace Analysis   Copper Tolerance  

Sequence-based Functional Metagenomics Reveals New Natural Diversity of Functional COPA Genes in Environmental Microbiomes The natural diversity of functional genes/proteins in environmental microbiomes is an essential component of evolutionary and bioengineering research. To gain a deeper understanding of the diversity of the copper (Cu) resistanc...

Novel Coumarins Derivatives for A. baumannii Lung Infection Developed by High-throughput Screening and Reinforcement Learning

Chemistry, Organic Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases,
A. baumannii   coumarins   lung infection   high-throughput screening   reinforcement learning   structure optimization  

Review of Research on Treatment of Lung Infections with Novel Coumarin Derivatives Background With the increasing antibiotic resistance, especially the problem of Acinetobacter baumannii’s resistance to antibiotics, researchers worldwide have begun to search for new antimicrobial agents. This Gram-negative bacterium, with its high survivability and...

Doxycycline-loaded calcium phosphate nanoparticles with a pectin coat can ameliorate lipopolysaccharide-induced neuroinflammation via enhancing AMPK

Chemistry, Nanoscience, Medicine, Neurology, Life Sciences, Biochemistry, Immunology,
neuroinflammation   AMPK   TLR-4   NRF2   IL-6   doxycycline  

Protective Effect of Doxycycline-Loaded Calcium Phosphate Nanoparticles on LPS-Induced Neuroinflammation in Mice In the field of neuroscience research, neuroinflammation is an important pathological feature of many neurological diseases. Neuroinflammation is a complex response of the central nervous system (CNS) to various damaging triggers (such a...

Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Chemistry, Nanoscience, Medicine, Geriatrics, Neurology, Life Sciences, Bioengineering,
NF-κB   NLRP3   Neuroinflammation   Aging   Tauopathy   Cognitive Function  

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...