Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Deciphering Antagonist Selectivity of Endothelin Receptors: Insights from Cryo-EM-Based Structural Studies Academic Background Endothelin (ET) is a potent vasoconstrictor peptide that plays a significant role in regulating cardiovascular functions. The endothelin family includes ET-1, ET-2, and ET-3, which regulate vascular tone and cardiovascular ...

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...