Antimicrobial Activity of α/β Hybrid Peptides Incorporating tbu-β3,3ac6c Against Methicillin-Resistant Staphylococcus aureus

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Microbiology,
antimicrobial peptides   methicillin-resistant Staphylococcus aureus   β-amino acids   multi-drug resistance   antimicrobial activity   peptide synthesis   biofilm inhibition  

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Structure-Activity Relationship Studies of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Pharmacy,
onychomycosis   antifungal agent   structure-activity relationship   topical treatment   ME1111   nail permeability   keratin binding  

Structure-Activity Relationship Studies of ME1111—A Novel Antifungal Agent for Topical Treatment of Onychomycosis Background Onychomycosis is a globally prevalent disease affecting approximately 5.5% of the world’s population. Among its subtypes, distal-lateral subungual onychomycosis (DLSO) is the most common. The treatment of onychomycosis typica...

Nonemissive Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy in a 'Signal On' Mode

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Biochemistry,
Iridium(III) solvent complex   Self-reporting photosensitizer   Phototherapeutic efficacy   Signal on   Immunogenic cell death  

Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy Academic Background Cancer is one of the leading causes of global mortality, significantly impacting patients’ quality of life. In recent years, photodynamic therapy (PDT) has garnered considerable attention as a promising technology for cancer...

Rapid and Large-Scale Synthesis of Chiral and Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring

Chemistry, Nanoscience, Analytical Chemistry, Physical Chemistry, Medicinal Chemistry, Materials Chemistry, Medicine, Medical Imaging, Life Sciences, Biochemistry,
sulfur quantum dots   amino acid   fluorescence   chirality   cellular imaging   temperature monitoring   inflammation diagnostics  

Rapid and Large-Scale Synthesis of Chiral Fluorescent Sulfur Quantum Dots for Intracellular Temperature Monitoring Academic Background Fluorescent nanomaterials have broad application potential in fields such as energy harvesting, lighting displays, communication and information technology, biology, and medicine. Among them, sulfur quantum dots (SQ...

Unraveling the Applicability of LBL Coatings for Drug Delivery in Dental Implant-Related Infection Treatment

Chemistry, Medicinal Chemistry, Materials Chemistry, Materials Science, Medicine, Oral Sciences,
antimicrobial coating   layer-by-layer system   drug delivery system   dental implants   peri-implantitis  

Application of LBL Coatings in the Treatment of Dental Implant-Related Infections Background Dental implant-related infections, particularly peri-implantitis, are inflammatory diseases caused by bacterial biofilms, leading to progressive destruction of surrounding tissues. Peri-implantitis not only may result in implant loss but also can trigger mo...