Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation

Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...

The Endocannabinoid 2-Arachidonoylglycerol is Released and Transported on Demand via Extracellular Microvesicles

Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...

Temporal Autocorrelation is Predictive of Age—An Extensive MEG Time-Series Analysis

Brain Age Prediction Study Based on MEG Time Series Academic Background With the extension of human lifespan, understanding changes in the brain throughout the life cycle has become increasingly important. The structure and function of the brain undergo significant changes with age, which not only affect cognitive functions but are also closely rel...

Deep Learning to Quantify the Pace of Brain Aging in Relation to Neurocognitive Changes

As the global aging problem intensifies, the incidence of neurodegenerative diseases (such as Alzheimer’s Disease, AD) is increasing year by year. Brain aging (Brain Aging, BA) is one of the significant risk factors for neurodegenerative diseases, but it does not completely align with chronological age (Chronological Age, CA). Traditional methods f...

Enhancing Passive Cavitation Imaging Using Pth Root Compression Delay, Sum, and Integrate Beamforming: In Vitro and In Vivo Studies

Application of pth Root Compression Delay, Sum and Integrate Beamforming in Passive Cavitation Imaging Academic Background Passive Cavitation Imaging (PCI) is a technique used to monitor bubble activity during ultrasound therapy, widely applied in treatment scenarios such as drug delivery and tissue ablation (e.g., Histotripsy). However, existing P...