Development and External Validation of Prediction Risk Scores (StrISK and NOFA) to Predict Immediate Surgical Need in Adhesive Small Bowel Obstruction: An Observational Prospective Multicentre Study

Background Introduction Adhesive Small Bowel Obstruction (ASBO) is one of the leading causes of emergency admissions, accounting for approximately 60% of all small bowel obstruction cases. ASBO is often caused by postoperative intra-abdominal adhesions, with patients presenting symptoms such as abdominal pain, vomiting, and constipation. While most...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Discussing Expected Long-Term Quality of Life in the ICU: Effect on Experiences and Outcomes of Patients, Family, and Clinicians—A Randomized Clinical Trial

The Impact of Discussing Long-Term Quality of Life Predictions in the ICU on Patients, Families, and Healthcare Professionals Academic Background Patients discharged from the Intensive Care Unit (ICU) often face a range of physical, psychological, and cognitive issues, collectively referred to as Post-Intensive Care Syndrome (PICS). Despite improve...

ESICM Consensus-Based Recommendations for the Management of Very Old Patients in Intensive Care

ESICM Consensus: Management and Challenges of Very Old Patients in Critical Care Academic Background With the global aging population, the proportion of “very old patients” (aged 80 years and above) in intensive care units (ICUs) is rapidly increasing. This group is characterized by functional impairments and a high prevalence of complex multimorbi...

Serum Chloride Concentration and Outcomes in Adults Receiving Intravenous Fluid Therapy

The Relationship Between Serum Chloride Concentration and Intravenous Fluid Therapy Outcomes Background Introduction In the intensive care unit (ICU), intravenous fluid therapy is a common treatment, with “balanced solutions” and 0.9% sodium chloride solution (saline) being the most commonly used fluids. In recent years, multiple randomized control...