Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Enabling tumor-specific drug delivery by targeting the Warburg effect of cancer

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Warburg effect   lactate-responsive   tumor microenvironment   targeted drug release   Janus nanoparticles   tumor specificity   drug delivery  

Research on a New Platform for Tumor-Specific Drug Delivery Targeting the Warburg Effect Cancer remains a global health challenge. Traditional cancer treatments, such as chemotherapy and radiotherapy, often come with significant side effects due to their inability to distinguish between tumor tissues and healthy tissues, leading to damage in the la...

Protein-functionalized and intrinsically radiolabeled 188Re oxide nanoparticles: advancing cancer therapy through concurrent radio-photothermal effects

Chemistry, Nanoscience, Medicinal Chemistry, Materials Chemistry, Medicine, Medical Imaging, Oncology,
protein-functionalized   188Re   radiotherapy   photothermal therapy   tumor treatment   nanoparticles   dual-modality imaging  

Protein-Functionalized and Intrinsically Radiolabeled [188Re]ReOx Nanoparticles: Breakthrough Application in Multimodal Synergistic Cancer Therapy Cancer remains one of the leading causes of death globally, despite significant progress in medical science over the past few decades. However, early detection and treatment methods still face significan...

Ion-Concentration-Dependent Dynamic Mechanism of Thiolactic-Acid-Capped Gold Nanoclusters Revealed by Fluorescence Spectra and Two-Dimensional Correlation Spectroscopy

Physics, Optics, Chemistry, Nanoscience, Analytical Chemistry, Physical Chemistry, Inorganic Chemistry,
gold nanoclusters   two-dimensional correlation spectroscopy   anti-galvanic reaction   photoluminescence mechanism   fluorescence spectroscopy   size effect  

Background and Research Questions Atomic gold nanoclusters (AuNCs), with particle sizes typically not exceeding 2 nanometers, have garnered extensive attention in recent years due to their unique photophysical properties, making them highly advantageous in biomedicine, catalysis, and sensing. These properties include excellent catalytic activity, t...

Single-Molecule Dynamic Structural Biology with Vertically Arranged DNA on a Fluorescence Microscope

Chemistry, Nanoscience, Life Sciences, Biochemistry, Biophysics,
single-molecule fluorescence   DNA-protein interactions   graphene energy transfer   dynamic structural biology   super-resolution microscopy  

Single-Molecule Dynamic Structural Biology: Breakthrough in Observing DNA-Protein Interactions Using Graphene Background Introduction The intricate and precise interactions between DNA and proteins play a crucial role in fundamental biological functions such as DNA replication, transcription, and repair. However, observing these interaction process...