A Dual-Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide-Induced Sepsis

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Infectious Diseases, Basic Medical Sciences, Life Sciences, Biochemistry, Bioengineering, Immunology,
lactate removal   vascular hyperpermeability   sepsis   lipopolysaccharides   nanohybrids   inflammatory response   endothelial barrier function  

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...

New Advances in Periodontal Functional Materials Based on Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies

Chemistry, Nanoscience, Polymer Chemistry, Medicinal Chemistry, Medicine, Oral Sciences, Life Sciences, Biochemistry, Bioengineering, Immunology, Microbiology,
periodontitis   antibacterial materials   anti-inflammatory therapy   tissue regeneration   multifunctional materials   biomaterials   innovative treatment  

A Review on Novel Periodontal Functional Materials: Comprehensive Exploration of Antibacterial, Anti-inflammatory, and Tissue Regeneration Strategies Academic Background and Research Significance With the accelerating trend of global population aging, the concern for oral health issues is increasing. Periodontitis, as a common bacterial infectious ...

Enhancing Immunomodulation and Osseointegration of Bone Implants via Thrombin-Activated Platelet-Rich Plasma Self-Assembly

Chemistry, Medicinal Chemistry, Medicine, Orthopedics, Life Sciences, Biochemistry, Bioengineering, Immunology,
bone implants   thrombin   platelet-rich plasma   immunomodulation   osseointegration   self-assembly   tissue repair  

Enhancing Immunomodulation and Osseointegration of Bone Implants: A Detailed Overview of Thrombin-Activated Platelet-Rich Plasma (PRP) Self-Assembly Technology Background Introduction To address the challenge of bone defect repair, bone implants play a critical role in modern medicine. However, existing bone implant materials like Polyetheretherket...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Dual Ferroptosis Induction in N2-TANs and TNBC Cells via FTH1 Targeting: A Therapeutic Strategy for Triple-Negative Breast Cancer

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
ferroptosis   triple-negative breast cancer   N2-TANs   FTH1   immune microenvironment   ferritinophagy   novel cancer therapy  

Dual Ferroptosis Induction via FTH1 Targeting: A New Therapeutic Strategy for Triple-Negative Breast Cancer (TNBC) Background: Why Conduct This Study? Breast cancer is one of the most common cancer types worldwide, accounting for 11.7% of all new cancer cases globally. Among its several subtypes, triple-negative breast cancer (TNBC) stands out for ...