A Deep Learning Approach for Rational Ligand Generation with Toxicity Control

Chemistry, Medicinal Chemistry, Information Science, Artificial Intelligence, Life Sciences, Biochemistry,
deep learning   ligand generation   toxicity control   drug design   computational model   block-based generation   molecular optimization  

Latest Research on Deep Learning Applied to Target Protein Ligand Generation: Proposal and Validation of the DeepBlock Framework Background and Research Problem In the drug discovery process, finding ligand molecules that bind to specific proteins has always been a core objective. However, current virtual screening methods are often limited by the ...

Glepaglutide-Loaded Foam for Inducing Mucosal Healing in Inflammatory Bowel Disease Treatment

Chemistry, Medicinal Chemistry, Medicine, Medical Laboratory Science, Gastroenterology, Pharmacy, Life Sciences, Biochemistry, Immunology,
Mucosal Healing   Inflammatory Bowel Disease   Glepaglutide   Local Delivery   Anti-inflammatory Properties  

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

Efficacy and Cellular Mechanism of Biomimetic Marine Adhesive Protein-Based Coating Against Skin Photoaging

Chemistry, Nanoscience, Polymer Chemistry, Medicinal Chemistry, Materials Chemistry, Medicine, Medical Laboratory Science, Life Sciences, Cell Biology,
biomimetic   marine adhesive protein   skin photoaging   antioxidant   tissue repair   wet adhesion   protective coating  

Research Advances on the Use of Biomimetic Marine Adhesive Protein Coating for Skin Photoaging Prevention Skin photoaging is a significant global health issue, particularly for individuals exposed to prolonged ultraviolet (UV) radiation in outdoor environments. Its manifestations include a reduction in collagen, increased wrinkles, loss of skin ela...

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Basic Medical Sciences, Oral Sciences, Life Sciences, Cell Biology, Immunology,
Cold Atmospheric Plasma   Oral Ulcers   Nanogel   Inflammation Regulation   Epidermal Growth Factor Receptor   Biocompatibility   Therapeutic Enhancement  

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

A Potential 3-in-1 Combined Anti-SARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Infectious Diseases, Respiratory System, Pharmacy, Life Sciences, Biochemistry, Immunology,
COVID-19   metal-organic frameworks   antiviral therapy   pulmonary treatment   Favipiravir   heparin   drug delivery  

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...