Computationally Designed Proteins Mimic Antibody Immune Evasion in Viral Evolution

Academic Background The continuous mutation of SARS-CoV-2 has posed ongoing challenges to the efficacy of vaccines and antibody therapies. Traditional evaluation methods can only test against existing variants and fail to predict future immune escape mutations. To address this, Noor Youssef and colleagues developed the EVE-Vax (Evolutionary Variant...

Differential Elimination of Marked Sex Chromosomes Enables Production of Nontransgenic Male Mosquitoes in a Single Strain

Research Background The Aedes aegypti mosquito is a primary vector for arboviruses such as dengue and Zika. Current genetic control strategies relying on the release of non-biting males (e.g., Sterile Insect Technique, SIT, or Wolbachia-based Incompatible Insect Technique, IIT) face a critical bottleneck: how to efficiently and cost-effectively iso...

Persistent Pseudopod Splitting is an Effective Chemotaxis Strategy in Shallow Gradients

Academic Background Chemotaxis is a critical behavior in which cells or microorganisms move directionally along chemical gradients, playing vital roles in physiological processes such as immune responses, wound healing, and pathogen infections. However, how cells select optimal motility modes (e.g., pseudopod splitting or de novo formation) in comp...

Cross-Feeding Creates Tipping Points in Microbiome Diversity

Academic Background Microbiomes are among the most diverse ecosystems on Earth, consisting of hundreds of functionally distinct microbial populations interacting through complex resource exchange networks. However, a long-standing unresolved question is: How is this extraordinary diversity maintained through metabolic interactions among populations...

Paving the Way for Social Touch at a Distance: Sonifying Tactile Interactions and Their Underlying Emotions

Academic Background Touch is one of the earliest developed human senses and is crucial for physical and mental well-being. However, with the increasing prevalence of virtual communication, the lack of tactile interaction in remote exchanges may lead to psychological issues such as anxiety and loneliness. Previous studies have shown that touch can e...