Transcriptomic Analysis of the m6A Reader YTHDF2 in the Maintenance and Differentiation of Human Embryonic Stem Cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
m6A modification   YTHDF2   human embryonic stem cells   neuroectoderm differentiation   transcriptomics   ROBO1  

1. Research Background and Significance Over the past decade, the role of epigenetics in regulating cell fate decisions and disease development has become increasingly prominent. As a crucial part of epigenetic regulation, modifications at the RNA level—especially N6-methyladenosine (m6A)—have been confirmed to be widely present within eukaryotic m...

Rabbit Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells for Enhanced Wound Healing

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Bioengineering,
induced pluripotent stem cells   mesenchymal stem cells   rabbit   wound healing   regenerative medicine   SB431542   differentiation  

Academic Background and Research Motivation In recent years, the field of stem cell and regenerative medicine has developed rapidly. Due to their multipotency and self-renewal capacity, stem cells have become a vital cell source for tissue repair and regeneration. Among the many types of stem cells, Mesenchymal Stem Cells (MSCs) have drawn consider...

Neuropeptide Substance P Modulates Stem Cell Fate to Promote Wound Healing and Epidermal Stratification via Asymmetric Divisions

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Substance P   stem cell fate   wound healing   epidermal stratification   asymmetric division   sensory innervation   re-epithelialization  

Neuropeptide Substance P Regulates Stem Cell Division to Promote Wound Healing and Epidermal Stratification: An In-depth Interpretation of the Latest Study by Khalifa et al. Research Background and Scientific Questions Wound healing following skin injury has long been a central focus in both clinical and basic medical sciences. With aging, diabetes...

E3 Ligase TRIM63 Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells by Catalyzing K27-Linked Cysteine Ubiquitination of MYH11

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
TRIM63   mesenchymal stem cells   chondrogenic differentiation   ubiquitination   MYH11   cartilage repair   osteoarthritis  

Research Progress on the Role of E3 Ubiquitin Ligase TRIM63 in Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells — An Interpretation of the Paper “E3 ligase TRIM63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of MYH11” 1. Academic Background and Research Motivati...

Overexpression of ZIC1 Transcription Factor in Segmental Bone Defects Promotes Brown Adipogenic and Osteogenic Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
ZIC1 transcription factor   osteogenic differentiation   brown adipogenesis   segmental bone defect   stem cells   human adipose progenitor cells   hedgehog signaling  

1. Academic Background and Research Significance Human bone tissue possesses a certain degree of self-healing capability. However, after suffering from severe trauma, tumor resection, infection, or congenital deformity, leading to large-volume bone defects, this regenerative ability becomes limited. The so-called “critical size bone defect” refers ...