Generative Prediction of Causal Gene Sets Responsible for Complex Traits

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
gene regulatory networks   complex traits   generative deep learning   variational autoencoder   causal gene sets   phenotypic variation   polygenic diseases  

Generative Deep Learning for Predicting Causal Gene Sets of Complex Traits: PNAS Landmark New Method Explained I. Academic Background and Research Motivation The Dilemma of Complex Traits The relationship between genotype and phenotype has long been one of the core issues in biology and genetics. This challenge is especially prominent in the study ...

The Dependence of Amino Acid Backbone Conformation on the Translated Synonymous Codon Is Not Statistically Significant

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Biophysics,
synonymous codon   protein structure   dihedral angle   statistical analysis   protein folding   translation regulation  

Re-evaluating the Influence of Synonymous Codons on Protein Backbone Conformation — A Dialectic Under Rigorous Statistical Testing in Structural Biology 1. Academic Background and Research Motivation In the fields of molecular biology and structural biology, the relationship between codons and protein structure has long been a focal point of resear...

Cross-species modeling of plant genomes at single-nucleotide resolution using a pretrained DNA language model

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Bioengineering, Genetics, Botany,
plant genomics   deep learning   DNA language model   cross-species prediction   deleterious mutation   gene annotation   angiosperm  

A Milestone in Cross-Species Modeling of Plant Genomes: Creation and Breakthrough Application of the PlantCaduceus DNA Language Model I. Academic Background and Research Motivation In the past two decades, with the rapid development of high-throughput sequencing technology, over 1,000 plant genomes have been published, and this number is expected t...

Bias-Aware Training and Evaluation of Link Prediction Algorithms in Network Biology

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
link prediction   network biology   bias   protein-protein interaction   graph machine learning   algorithm evaluation  

Revealing “Rich Node” Bias in Link Prediction Algorithms and Countermeasures — An Interpretation of “Bias-aware Training and Evaluation of Link Prediction Algorithms in Network Biology” 1. Academic Background and Motivation Over the past decade, network biology has played an increasingly important role in uncovering associations and functions of bi...

Development and Validation of a Proteomic Signature of Healthspan

Medicine, Environmental and Public Health, Medical Laboratory Science, Geriatrics, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
healthspan   proteomics   biological aging biomarkers   aging biomarkers   UK Biobank   healthy aging  

1. Academic Background: From Lifespan Extension to the Enhancement of Healthspan With the improvement of global medical and socioeconomic standards since the 20th century, overall human lifespan has significantly increased, especially in developing countries. However, healthspan—the number of years an individual lives in a state of complete health,...