Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Medicine, Infectious Diseases, Cardiovascular System, Life Sciences, Microbiology,
Klebsiella pneumoniae   extracellular vesicles   endothelial dysfunction   endothelial senescence   SIRT1   hypertension   inflammatory response  

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

Staphylococcus aureus Vesicles Impair Cutaneous Wound Healing through p38 MAPK-MERTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Immunology, Microbiology,
Staphylococcus aureus   extracellular vesicles   wound healing   efferocytosis   MERTK  

Staphylococcus Aureus Vesicles Impair Cutaneous Wound Healing Through p38 MAPK-MerTK Cleavage-Mediated Inhibition of Macrophage Efferocytosis Background Introduction Staphylococcus aureus (S. aureus) is one of the primary pathogens causing chronic wound infections, particularly in diabetic patients, with an infection rate as high as 65%. One of the...

Tracing Carriage, Acquisition, and Transmission of ESBL-Producing Escherichia coli Over Two Years in a Tertiary Care Hospital

Medicine, Infectious Diseases, Environmental and Public Health, Life Sciences, Microbiology,
ESBL-producing Escherichia coli   nosocomial acquisition   antibiotic selective pressure   community setting   hospital setting   ST131 clade  

Report on a Study of the Dynamics of Carriage, Acquisition, and Transmission of ESBL-Producing E. coli (ESBL-EC) in Non-ICU Hospital Wards Over Two Years Antimicrobial resistance is an increasingly significant global public health issue, with the rapid dissemination of extended-spectrum beta-lactamase-producing (ESBL) Enterobacterales, such as Kleb...

Revisiting Mutational Resistance to Ampicillin and Cefotaxime in Haemophilus influenzae

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Genetics, Microbiology,
Haemophilus influenzae   ampicillin resistance   cefotaxime resistance   BLNAR   MIC   genome-wide association study   phylogenomics  

Revisiting Mutational Resistance to Ampicillin and Cefotaxime in Haemophilus influenzae Background and Motivation for the Study Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract infections and invasive infections such as septicemia and meningitis, particularly in infants, the elderly, and immunoco...

Comprehensive Pathogen Identification and Antimicrobial Resistance Prediction from Positive Blood Cultures Using Nanopore Sequencing Technology

Medicine, Infectious Diseases, Medical Laboratory Science, Life Sciences, Microbiology,
pathogen identification   antimicrobial resistance prediction   positive blood cultures   real-time sequencing   nanopore sequencing   adaptive sampling  

Report on the Research Paper: Comprehensive Pathogen Identification and Antimicrobial Resistance Prediction from Positive Blood Cultures Using Nanopore Sequencing Technology Academic Context Bloodstream infections (BSIs) are severe clinical conditions typically diagnosed through positive blood culture results and systemic signs of infection. BSIs c...

Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing

Medicine, Infectious Diseases, Environmental and Public Health, Life Sciences, Genetics, Microbiology,
genomic surveillance   multidrug-resistant organisms   long-read sequencing   nanopore sequencing   MLST   WGMLST   WGS  

Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing Research Background Multidrug-resistant organisms (MDROs) are a significant global public health threat. These organisms exhibit resistance to multiple antibiotics, making infections challenging to treat and increasing healthcare costs. To effectively monitor and co...