Antimicrobial Activity of α/β Hybrid Peptides Incorporating tbu-β3,3ac6c Against Methicillin-Resistant Staphylococcus aureus

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Causal Relationship Between Intestinal Microbiota, Inflammatory Cytokines, Peripheral Immune Cells, Plasma Metabolome and Parkinson's Disease: A Mediation Mendelian Randomization Study

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...

Synthesis of Palladium Nanoparticles by Electrode-Respiring Geobacter sulfurreducens Biofilms

Synthesis of Palladium Nanoparticles by Electrode-Respiring Geobacter sulfurreducens Biofilms Research Background In modern industry and environmental science, palladium (Pd) serves as a crucial catalyst widely used in pharmaceuticals, agriculture, and chemical industries. However, traditional methods for synthesizing palladium nanoparticles (Pd NP...

Challenges to Mediterranean Fagaceae Ecosystems Affected by Phytophthora cinnamomi and Climate Change: Integrated Pest Management Perspectives

Challenges to Mediterranean Fagaceae Ecosystems Affected by Phytophthora cinnamomi and Climate Change Academic Background The Mediterranean Fagaceae ecosystems, including oak trees (Quercus ilex and Quercus suber) and chestnut trees (Castanea sativa), are vital ecological and economic resources in southern Europe. However, in recent years, these ec...

Forest Tree Virome as a Source of Tree Diseases and Biological Control Agents

Forest Tree Virome as a Source of Tree Diseases and Biological Control Academic Background The health of forest ecosystems is crucial for global ecological balance and economic development. However, the health of forest trees is threatened by various pathogens, including fungi, oomycetes, bacteria, viruses, as well as insect and nematode pests. Alt...

Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...