Modulating Hetero-Multimetallic Atoms in Covalent Organic Frameworks for Efficient Oxidization of Olefin Compounds

In the field of synthetic chemistry, modulating the quantity and location of different metal centers to achieve synergistic, tandem, or cooperative effects has always been a technical challenge. Hetero-multinuclear catalysts have garnered significant attention due to their advantages such as high selectivity, cascading production, and specific chem...

Live Bacterial Chemistry in Biomedicine

Background Introduction The application of live bacteria in the biomedical field has garnered significant attention in recent years. Traditionally, bacteria were viewed as pathogens that needed to be eradicated. However, with the advancement of modern bacteriology, there has been a growing recognition of the complex symbiotic relationship between b...

Synthesis of Securingine B Enables Photoresponsive Materials Design

Research Background Natural products have long played a crucial role in drug discovery, providing many biologically active compounds and fundamental principles for drug development. However, the synthetic exploration of natural products is not limited to the pharmaceutical field; their applications in materials science are gradually gaining attenti...

Spectinomycin-Loaded Antibacterial Polyvinyl Alcohol/Silver Oxide Nanobiocomposite Hydrogel: Synthesis, Characterization, Swelling, Cytotoxicity, and Controlled Drug Release Carrier

Academic Background In the field of drug delivery, achieving long-term and controlled release of drugs is a significant research direction. Hydrogels, as materials with excellent biocompatibility and degradability, have been widely used in drug delivery, tissue engineering, and wound dressing. However, the low mechanical strength of traditional hyd...

Pseudomonas fluorescens–Based Biogenic Silver Nanoparticles: A Green Solution for Brown Leaf Spot Disease in Rice

Academic Background Rice (Oryza sativa L.) is a globally important food crop, providing a primary source of calories for approximately one-fifth of the world’s population. However, rice production faces various biotic and abiotic stresses, leading to reduced yields. Among these, rice brown leaf spot disease, caused by the fungal pathogen Cochliobol...

Development and Characterization of Baricitinib Nanoemulgel with Antiarthritic Effect in Rats

Academic Background Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial membrane of joints, leading to inflammation and erosive lesions. Approximately 0.5% to 1% of the global population is affected by this disease, particularly among the elderly, who often experience dysphagia, which limits the compliance ...

Synthesis and Characterization of Pyrogallol Silver Nanoparticles and Pyrogallol Nanocomposites and Their Effects on Radiation-Induced Toxicity in HEK293 Cells

Academic Background Cancer is a complex and highly prevalent disease worldwide, causing nearly 10 million deaths annually. Early diagnosis and effective treatment are crucial for improving patient survival rates. Current cancer treatment modalities include surgery, chemotherapy, radiotherapy, and immunotherapy. Among these, radiotherapy is a critic...

Arabinoxylan-Incorporated Poly(ε-Caprolactone) Nanofiber Matrix Promotes Fibroblast Cell Adhesion and Proliferation

Academic Background Wound healing is a complex physiological process involving multiple coordinated stages, including hemostasis, inflammation, proliferation, and remodeling. However, in cases of severe trauma or chronic wounds, traditional treatments such as dressings and sutures often have limited efficacy. In recent years, the development of tis...

Synthesis, Physicochemical Characterization, and Antimicrobial Evaluation of Ureasil-Polyether Coatings with Silver Nanoparticles for Hospital Devices

Research Background Nosocomial infections are a common and serious problem in healthcare settings, particularly on reusable medical devices, where cross-contamination and biofilm formation are major causes. To address this challenge, researchers have begun exploring the use of coating materials containing metallic nanoparticles to prevent microbial...

Effects of Bare and PEG Coated Gold Nanoparticles on RRM2 Protein: A Pathway Analysis and MD Simulations Approach

Academic Background Nanoparticles (NPs) have increasingly been applied in the medical field, particularly in bioimaging, biosensing, and drug delivery. Gold nanoparticles (AuNPs), due to their unique physicochemical properties, have become a focal point in biomedical research. However, despite their significant therapeutic potential, the biosafety ...