Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERP57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
ALS   protein disulfide isomerase   ERP57   TDP-43 pathology   ER stress  

Study on the Protective Effect of ERP57 on ALS-related Mutant TDP-43 in Neuronal Cells Introduction Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Almost all ALS cases (97%) and about 50% of frontotemporal dementia (FTD) cases show a pathological form of Tar-DNA binding protein-43 (TDP-43), indica...

Study on GABRA4 Gene Mutations and Neurological Phenotypes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry, Genetics, Biophysics,
GABRA4   Neurological Phenotype   Developmental Delay   Behavioral Abnormalities   Epilepsy  

New Scientific Research Reveals Association Between GABRA4 Gene and Neurological Phenotypes Research Background In recent years, significant progress has been made in the study of epilepsy and developmental disorder syndromes associated with single gene mutations. GABAA receptors (gamma-aminobutyric acid sub-type A receptors, GABAARs) are heterogen...

Face-Specific Activity in the Ventral Stream Visual Cortex Linked to Conscious Face Perception

Face-Specific Activity in the Ventral Stream Visual Cortex Linked to Conscious Face Perception

Information Science, Artificial Intelligence, Life Sciences, Biophysics,
face-specific   conscious face perception   ventral stream visual cortex   intracranial EEG   neural activity  

Exploring the Relationship between Face-Specific Activity and Conscious Face Perception Introduction Face perception is a fundamental cognitive process that enables humans to effectively identify faces in the environment, thus facilitating better social interactions. Extensive research has identified a specific region in the ventral visual cortex o...

Comparative Molecular Taxonomics of Neurons in the Cingulate Cortex of Rhesus Monkey and Mouse via Single-Nucleus RNA Sequencing

Life Sciences, Cell Biology, Biophysics,
Rhesus Monkey   Mouse   Single-Nucleus RNA Sequencing   Neurons   Molecular Taxonomy   Cingulate Cortex  

Comparative Study of Molecular Taxonomy in Cortical Regions of Primates and Rodents The brain structure is complex, showing high complexity in both molecular and cellular composition. Current research on brain molecular taxonomy is mainly based on rodents. However, although primates and rodents have common ancestors, they diverged through different...

High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
Amblyopia   Magnesium   TRPM7   Binocular Vision   Neural Plasticity   Visual Cortex   Molecular Mechanism  

Mechanism Study of High Magnesium Promoting Binocular Vision Recovery in Amblyopia Patients: The Role of TRPM7 Abnormal visual experiences during critical periods of brain development can lead to visual function deficits, such as amblyopia. Current research suggests that high magnesium (Mg^2+) supplementation can restore synaptic plasticity in the ...