Diatom Phytochromes Integrate the Underwater Light Spectrum to Sense Depth

Report on the Study of Diatom Phytochromes Integrating Underwater Light Spectrum to Sense Depth Academic Background The distribution of light in marine ecosystems profoundly influences aquatic life. Light not only attenuates with depth but also undergoes significant spectral changes. However, research on how phytoplankton perceive these light chang...

The Conformational Space of RNase P RNA in Solution

The Conformational Space of RNase P RNA in Solution Academic Background The conformational diversity of RNA plays a crucial role in biology, particularly in processes such as RNA splicing, packaging, cellular transcriptional activation, and responses to environmental stimuli. However, traditional biophysical techniques have been unable to directly ...

Determining Structures of RNA Conformers Using AFM and Deep Neural Networks

Academic Background RNA (ribonucleic acid) is a crucial molecule in living organisms, involved in various biological processes such as gene expression, regulation, and catalysis. Although a significant portion of the human genome is transcribed into RNA, the structural study of RNA molecules remains a major challenge. RNA molecules typically exhibi...

Synaptic Basis of Feature Selectivity in Hippocampal Neurons

Synaptic Basis of Feature Selectivity in Hippocampal Neurons Academic Background A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals. Hippocampal CA1 pyramidal neurons (CA1PNs) exhibit one of the most striking forms of feature selectivity by forming spatially and contextually s...

Inferring Phase Transitions and Critical Exponents from Limited Observations with Thermodynamic Maps

Inferring Phase Transitions and Critical Exponents from Limited Observations with Thermodynamic Maps Academic Background Phase transitions are ubiquitous phenomena in nature, ranging from the boiling of water to the ferromagnetic-paramagnetic transition in magnetic materials, and even to conformational changes in biomolecules such as proteins and n...