Wavelet-Based Bracketing, Time–Frequency Beta Burst Detection: New Insights in Parkinson's Disease

Parkinson’s Disease Research Report: Beta Burst Behavior Analysis Using a Wavelet-Based Time-Frequency Detection Framework Background Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by motor dysfunction, including tremors, rigidity, and bradykinesia. Recent studies have linked motor impairments in PD to excessive sy...

A Conditional Protein Diffusion Model Generates Artificial Programmable Endonuclease Sequences with Enhanced Activity

A Conditional Protein Diffusion Model Generates Artificial Programmable Endonuclease Sequences with Enhanced Activity

Deep Learning-Driven Protein Design: Generating Functional Protein Sequences Using Conditional Diffusion Models Proteins are at the core of life sciences research and applications, offering countless possibilities due to their diversity and functional complexity. With advancements in deep learning technologies, protein design has reached a new pinn...

Molecular Mechanism of Prolactin-Releasing Peptide Recognition and Signaling via its G Protein-Coupled Receptor

Molecular Mechanism of Prolactin-Releasing Peptide Recognition and Signaling via its G Protein-Coupled Receptor

Analysis of the Molecular Recognition and Signal Transduction Mechanism of PRRP and PRRPR Research Background Neuropeptides, as the most abundant signaling molecules in the nervous system, have over 100 identified types and play critical roles in processes like metabolism, pain sensation, and reproduction. Among them, RF-amide neuropeptides are cha...

A Human Pluripotent Stem Cell-Based Somitogenesis Model Using Microfluidics

Study of Somite Formation Model Based on Microfluidic System Background and Research Motivation The formation of somites plays a crucial role in vertebrate embryonic development, significantly influencing the layout and functionality of the embryonic musculoskeletal system. Somite formation involves the segmentation of bilateral presomitic mesoderm...

Integration and Competition Between Space and Time in the Hippocampus

A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...