The Endocannabinoid 2-Arachidonoylglycerol is Released and Transported on Demand via Extracellular Microvesicles

Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...

GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea

GABAergic Synapses Between Auditory Efferent Neurons and Type II Spiral Ganglion Afferent Neurons in the Mouse Cochlea Background Introduction The complexity and precision of the auditory system have always been important topics in neuroscience research. As a key component of the auditory system, the interactions between cells and neurons within th...

Independent effects of the human circadian system and sleep/ eating cycles on caloric intake in adolescents vary by weight status

 

The Impact of Circadian Rhythms and Behavioral Cycles on Caloric Intake in Adolescents Varies by Weight Status Academic Background The prevalence of obesity continues to rise globally, particularly among adolescents, increasing the risk of various chronic diseases such as type 2 diabetes, hypertension, and cardiovascular disorders. While previous s...

Temporal Autocorrelation is Predictive of Age—An Extensive MEG Time-Series Analysis

Brain Age Prediction Study Based on MEG Time Series Academic Background With the extension of human lifespan, understanding changes in the brain throughout the life cycle has become increasingly important. The structure and function of the brain undergo significant changes with age, which not only affect cognitive functions but are also closely rel...

ATP-Sensitive Potassium Channels Alter Glycolytic Flux to Modulate Cortical Activity and Sleep

KATP Channels Modulate Cortical Activity and Sleep by Regulating Glycolytic Flux Academic Background Glucose serves not only as the primary energy source for the brain but also as a biosynthetic substrate for neurotransmitter synthesis. Changes in glycolytic flux can alter neurotransmitter synthesis, thereby modulating cortical electroencephalograp...