A PRM Mutation that Attenuates Dengue Virus Replication in Human Cells Enhances Midgut Infection in Mosquitoes

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Immunology, Microbiology,
Dengue Virus   PRM Mutation   Virus Replication   Mosquito Infection   1970s   South Pacific   Epidemiology  

Dengue Virus Research: Impact of Genetic Mutations on Virus Transmission and Discoveries Introduction This study was conducted by Allyson N. X. Choi et al. and published in Science Translational Medicine on July 31, 2024. The research aims to reveal the impact of genetic changes in dengue virus on its transmission ability and disease outbreaks duri...

A Self-Amplifying RNA Vaccine Prevents Enterovirus D68 Infection and Disease in Preclinical Models

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Bioengineering, Immunology, Microbiology,
RNA vaccine   Enterovirus D68   nonenveloped virus   antibody responses   vaccine platform   antigenic diversity   preventive vaccine  

A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...

Whole-Genome Sequencing Reveals Autooctoploidy in Chinese Sturgeon and Its Evolutionary Trajectories

Life Sciences, Genetics, Microbiology,
Chinese sturgeon   whole-genome sequencing   autooctoploid   polyploidization   diploidization   whole-genome duplication  

Whole-Genome Sequencing Reveals Autopolyploidy and Evolutionary Trajectory of Chinese Sturgeon Background Chinese sturgeon (Acipenser sinensis), as a member of the sturgeon subclass, is an ancient fish group. Due to its unique genome structure and economic value, the conservation and research of Chinese sturgeon are of great significance. Sturgeons...

Molecular Evolution of Protein Sequences and Codon Usage in Monkeypox Viruses

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Biochemistry, Genetics, Microbiology,
mpox virus   positive selection   opg027   accelerated evolution   codon usage bias  

Molecular Evolution of Monkeypox Virus Protein Sequences and Codon Usage Research Background The 2022 Monkeypox virus (MPXV) outbreak has caused significant global public health concern. However, the evolutionary mechanisms of MPXV remain not fully understood. MPXV is a linear double-stranded DNA virus belonging to the family Poxviridae, subfamily ...

The Effect of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces

Life Sciences, Biochemistry, Genetics, Microbiology,
silent gene cluster   streptomyces   sodium butyrate   protein modification   acetylation  

Multi-omics Data Reveals the Impact of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces Academic Background Streptomyces has attracted widespread attention due to its rich gene clusters and potential for producing a large number of natural products. Histone deacetylase (HDAC) inhibitors play an important role in histone m...

High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion

Medicine, Medical Laboratory Science, Gastroenterology, Life Sciences, Genetics, Microbiology,
host DNA depletion   colon tissue biopsy   shotgun metagenomic sequencing   microbiota   species discovery   disease progression  

High sensitivity of high-throughput metagenomic sequencing in colon tissue biopsies: Eliminating the impact of host DNA Background Evaluating bacterial taxonomic structure through next-generation sequencing without culturing has become a common method for studying the relationship between bacterial imbalance and various diseases. Previous studies h...